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A senolytic immunotoxin eliminates p16INK4a-positive T cells and ameliorates age-associated phenotypes of CD4+ T cells in a surface marker knock-in mouse.
Sugiyama, Yuma; Harada, Tanenobu; Kamei, Yuka; Yasuda, Tomoharu; Mashimo, Tomoji; Nishikimi, Akihiko; Maruyama, Mitsuo.
Afiliação
  • Sugiyama Y; Department of Inflammation and Immunosenescence, Geroscience Research Center, Research Institute, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan.
  • Harada T; Department of Inflammation and Immunosenescence, Geroscience Research Center, Research Institute, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan.
  • Kamei Y; Department of Inflammation and Immunosenescence, Geroscience Research Center, Research Institute, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan.
  • Yasuda T; Department of Immunology, Graduate School of Biomedical and Health Science, Hiroshima University, Hiroshima, Japan.
  • Mashimo T; Laboratory Animal Research Center, Institute of Medical Science, the University of Tokyo, Tokyo, Japan.
  • Nishikimi A; Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan. Electronic address: a-nishikimi@ncgg.go.jp.
  • Maruyama M; Department of Inflammation and Immunosenescence, Geroscience Research Center, Research Institute, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan; Department of Aging Research, Nagoya University Graduate School of Medicine, Nagoya, Japan. Electronic address: michan@ncgg.go.jp.
Exp Gerontol ; 174: 112130, 2023 04.
Article em En | MEDLINE | ID: mdl-36822486
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos T / Imunotoxinas Tipo de estudo: Risk_factors_studies Limite: Animals Idioma: En Revista: Exp Gerontol Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Japão País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos T / Imunotoxinas Tipo de estudo: Risk_factors_studies Limite: Animals Idioma: En Revista: Exp Gerontol Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Japão País de publicação: Reino Unido