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11ß-HSD1 inhibition in men mitigates prednisolone-induced adverse effects in a proof-of-concept randomised double-blind placebo-controlled trial.
Othonos, Nantia; Pofi, Riccardo; Arvaniti, Anastasia; White, Sarah; Bonaventura, Ilaria; Nikolaou, Nikolaos; Moolla, Ahmad; Marjot, Thomas; Stimson, Roland H; van Beek, André P; van Faassen, Martijn; Isidori, Andrea M; Bateman, Elizabeth; Sadler, Ross; Karpe, Fredrik; Stewart, Paul M; Webster, Craig; Duffy, Joanne; Eastell, Richard; Gossiel, Fatma; Cornfield, Thomas; Hodson, Leanne; Jane Escott, K; Whittaker, Andrew; Kirik, Ufuk; Coleman, Ruth L; Scott, Charles A B; Milton, Joanne E; Agbaje, Olorunsola; Holman, Rury R; Tomlinson, Jeremy W.
Afiliação
  • Othonos N; Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, OX3 7LE, UK.
  • Pofi R; Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, OX3 7LE, UK.
  • Arvaniti A; Department of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena, 324, 00161, Rome, Italy.
  • White S; Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, OX3 7LE, UK.
  • Bonaventura I; Department of Biological and Medical Sciences, Oxford Brookes University, Oxford, OX3 0BP, UK.
  • Nikolaou N; Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, OX3 7LE, UK.
  • Moolla A; Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, OX3 7LE, UK.
  • Marjot T; Department of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena, 324, 00161, Rome, Italy.
  • Stimson RH; Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, OX3 7LE, UK.
  • van Beek AP; Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, OX3 7LE, UK.
  • van Faassen M; Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, OX3 7LE, UK.
  • Isidori AM; Translational Gastroenterology Unit, NIHR Oxford Biomedical Research Centre, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, UK.
  • Bateman E; University/BHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, EH16 4TJ, UK.
  • Sadler R; Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
  • Karpe F; Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
  • Stewart PM; Department of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena, 324, 00161, Rome, Italy.
  • Webster C; Department of Immunology, Churchill Hospital, Oxford, OX3 7LE, UK.
  • Duffy J; Department of Immunology, Churchill Hospital, Oxford, OX3 7LE, UK.
  • Eastell R; Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, OX3 7LE, UK.
  • Gossiel F; Faculty of Medicine & Health, University of Leeds, Clarendon Way, Leeds, LS2 9NL, UK.
  • Cornfield T; Department of Pathology, University Hospitals Birmingham, NHS Foundation Trust, Birmingham, B15 2GW, UK.
  • Hodson L; Department of Pathology, University Hospitals Birmingham, NHS Foundation Trust, Birmingham, B15 2GW, UK.
  • Jane Escott K; Mellanby Centre for Musculoskeletal Research, Department of Oncology & Metabolism, Faculty of Medicine, Dentistry & Health, University of Sheffield, Sheffield, SR10 2RX, UK.
  • Whittaker A; Mellanby Centre for Musculoskeletal Research, Department of Oncology & Metabolism, Faculty of Medicine, Dentistry & Health, University of Sheffield, Sheffield, SR10 2RX, UK.
  • Kirik U; Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, OX3 7LE, UK.
  • Coleman RL; Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, OX3 7LE, UK.
  • Scott CAB; Business Development & Licensing, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.
  • Milton JE; Emerging Innovations Unit, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.
  • Agbaje O; Quantitative Biology, Discovery Sciences, BioPharmaceuticals R&D AstraZeneca, Mölndal, Sweden.
  • Holman RR; Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, OX3 7LE, UK.
  • Tomlinson JW; Diabetes Trials Unit, Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford, OX3 7LJ, UK.
Nat Commun ; 14(1): 1025, 2023 02 23.
Article em En | MEDLINE | ID: mdl-36823106
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Prednisolona / 11-beta-Hidroxiesteroide Desidrogenase Tipo 1 / Anti-Inflamatórios Tipo de estudo: Clinical_trials Limite: Humans / Male Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Reino Unido País de publicação: Reino Unido
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Prednisolona / 11-beta-Hidroxiesteroide Desidrogenase Tipo 1 / Anti-Inflamatórios Tipo de estudo: Clinical_trials Limite: Humans / Male Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Reino Unido País de publicação: Reino Unido