Integrated analyses reveal a hinge glycan regulates coronavirus spike tilting and virus infectivity.

Chmielewski, David; Wilson, Eric A; Pintilie, Grigore; Zhao, Peng; Chen, Muyuan; Schmid, Michael F; Simmons, Graham; Wells, Lance; Jin, Jing; Singharoy, Abhishek; Chiu, Wah

Chmielewski, David; Wilson, Eric A; Pintilie, Grigore; Zhao, Peng; Chen, Muyuan; Schmid, Michael F; Simmons, Graham; Wells, Lance; Jin, Jing; Singharoy, Abhishek; Chiu, Wah.

Afiliação

Chmielewski D; Biophysics Graduate Program, Stanford University, Stanford, CA 94305, USA.
Wilson EA; School of Molecular Sciences, Biodesign Institute, Arizona State University, Tempe, AZ USA.
Pintilie G; Department of Bioengineering, and of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA.
Zhao P; Complex Carbohydrate Research Center, University of Georgia, Athens, GA 30602, USA.
Chen M; Division of CryoEM and Bioimaging, SSRL, SLAC National Accelerator Laboratory, Stanford University, Menlo Park, CA 94025, USA.
Schmid MF; Division of CryoEM and Bioimaging, SSRL, SLAC National Accelerator Laboratory, Stanford University, Menlo Park, CA 94025, USA.
Simmons G; Vitalant Research Institute, San Francisco, CA, 94118, USA.
Wells L; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, 94143, USA.
Jin J; Complex Carbohydrate Research Center, University of Georgia, Athens, GA 30602, USA.
Singharoy A; Department of Bioengineering, and of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA.
Chiu W; Vitalant Research Institute, San Francisco, CA, 94118, USA.

Res Sq ; 2023 Feb 15.

Article em En | MEDLINE | ID: mdl-36824920

Palavras-chave

coronavirus; cryoET; glycan; infectivity; mass spectroscopy; molecular dynamics

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Res Sq Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos

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