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How to Identify Advanced Fibrosis in Adult Patients with Non-Alcoholic Fatty Liver Disease (NAFLD) and Non-Alcoholic Steatohepatitis (NASH) Using Ultrasound Elastography-A Review of the Literature and Proposed Multistep Approach.
Taru, Madalina-Gabriela; Neamti, Lidia; Taru, Vlad; Procopciuc, Lucia Maria; Procopet, Bogdan; Lupsor-Platon, Monica.
Afiliação
  • Taru MG; Hepatology Department, Regional Institute of Gastroenterology and Hepatology "Octavian Fodor", 400162 Cluj-Napoca, Romania.
  • Neamti L; Faculty of Medicine, "Iuliu Hatieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.
  • Taru V; Department of Medical and Surgical Sciences, University of Bologna, 40126 Bologna, Italy.
  • Procopciuc LM; Hepatology Department, Regional Institute of Gastroenterology and Hepatology "Octavian Fodor", 400162 Cluj-Napoca, Romania.
  • Procopet B; Faculty of Medicine, "Iuliu Hatieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.
  • Lupsor-Platon M; Hepatology Department, Regional Institute of Gastroenterology and Hepatology "Octavian Fodor", 400162 Cluj-Napoca, Romania.
Diagnostics (Basel) ; 13(4)2023 Feb 19.
Article em En | MEDLINE | ID: mdl-36832276
Non-alcoholic fatty liver disease (NAFLD), and its progressive form, non-alcoholic steatohepatitis (NASH), represent, nowadays, real challenges for the healthcare system. Liver fibrosis is the most important prognostic factor for NAFLD, and advanced fibrosis is associated with higher liver-related mortality rates. Therefore, the key issues in NAFLD are the differentiation of NASH from simple steatosis and identification of advanced hepatic fibrosis. We critically reviewed the ultrasound (US) elastography techniques for the quantitative characterization of fibrosis, steatosis, and inflammation in NAFLD and NASH, with a specific focus on how to differentiate advanced fibrosis in adult patients. Vibration-controlled transient elastography (VCTE) is still the most utilized and validated elastography method for liver fibrosis assessment. The recently developed point shear wave elastography (pSWE) and two-dimensional shear wave elastography (2D-SWE) techniques that use multiparametric approaches could bring essential improvements to diagnosis and risk stratification.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: Diagnostics (Basel) Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Romênia País de publicação: Suíça

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: Diagnostics (Basel) Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Romênia País de publicação: Suíça