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Recent Advances in Polymeric Drug Delivery Systems for Peripheral Nerve Regeneration.
Bianchini, Marta; Micera, Silvestro; Redolfi Riva, Eugenio.
Afiliação
  • Bianchini M; The BioRobotics Institute, Department of Excellence in Robotics and AI, Scuola Superiore Sant'Anna, 56127 Pisa, Italy.
  • Micera S; The BioRobotics Institute, Department of Excellence in Robotics and AI, Scuola Superiore Sant'Anna, 56127 Pisa, Italy.
  • Redolfi Riva E; Translational Neuroengineering, Centre for Neuroprosthetics and Institute of Bioengineering, School of Engineering, École Polytechnique Fédérale de Lausanne (EPFL), 1000 Lausanne, Switzerland.
Pharmaceutics ; 15(2)2023 Feb 14.
Article em En | MEDLINE | ID: mdl-36839962
ABSTRACT
When a traumatic event causes complete denervation, muscle functional recovery is highly compromised. A possible solution to this issue is the implantation of a biodegradable polymeric tubular scaffold, providing a biomimetic environment to support the nerve regeneration process. However, in the case of consistent peripheral nerve damage, the regeneration capabilities are poor. Hence, a crucial challenge in this field is the development of biodegradable micro- nanostructured polymeric carriers for controlled and sustained release of molecules to enhance nerve regeneration. The aim of these systems is to favor the cellular processes that support nerve regeneration to increase the functional recovery outcome. Drug delivery systems (DDSs) are interesting solutions in the nerve regeneration framework, due to the possibility of specifically targeting the active principle within the site of interest, maximizing its therapeutical efficacy. The scope of this review is to highlight the recent advances regarding the study of biodegradable polymeric DDS for nerve regeneration and to discuss their potential to enhance regenerative performance in those clinical scenarios characterized by severe nerve damage.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Pharmaceutics Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Itália

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Pharmaceutics Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Itália