Mechanotransduction in tumor dynamics modeling.
Phys Life Rev
; 44: 279-301, 2023 03.
Article
em En
| MEDLINE
| ID: mdl-36841159
ABSTRACT
Mechanotherapy is a groundbreaking approach to impact carcinogenesis. Cells sense and respond to mechanical stimuli, translating them into biochemical signals in a process known as mechanotransduction. The impact of stress on tumor growth has been studied in the last three decades, and many papers highlight the role of mechanics as a critical self-inducer of tumor fate at the in vitro and in vivo biological levels. Meanwhile, mathematical models attempt to determine laws to reproduce tumor dynamics. This review discusses biological mechanotransduction mechanisms and mathematical-biomechanical models together. The aim is to provide a common framework for the different approaches that have emerged in the literature from the perspective of tumor avascularity and to provide insight into emerging mechanotherapies that have attracted interest in recent years.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Mecanotransdução Celular
/
Neoplasias
Limite:
Humans
Idioma:
En
Revista:
Phys Life Rev
Assunto da revista:
BIOFISICA
Ano de publicação:
2023
Tipo de documento:
Article