Assessing engineered tissues and biomaterials using ultrasound imaging: In vitro and in vivo applications.
Biomaterials
; 296: 122054, 2023 05.
Article
em En
| MEDLINE
| ID: mdl-36842239
ABSTRACT
Quantitative assessment of the structural, functional, and mechanical properties of engineered tissues and biomaterials is fundamental to their development for regenerative medicine applications. Ultrasound (US) imaging is a non-invasive, non-destructive, and cost-effective technique capable of longitudinal and quantitative monitoring of tissue structure and function across centimeter to sub-micron length scales. Here we present the fundamentals of US to contextualize its application for the assessment of biomaterials and engineered tissues, both in vivo and in vitro. We review key studies that demonstrate the versatility and broad capabilities of US for clinical and pre-clinical biomaterials research. Finally, we highlight emerging techniques that further extend the applications of US, including for ultrafast imaging of biomaterials and engineered tissues in vivo and functional monitoring of stem cells, organoids, and organ-on-a-chip systems in vitro.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Materiais Biocompatíveis
/
Engenharia Tecidual
Tipo de estudo:
Diagnostic_studies
Idioma:
En
Revista:
Biomaterials
Ano de publicação:
2023
Tipo de documento:
Article