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Characteristics, Mortality, and Clinical Outcomes of Hospitalized Patients with COVID-19 and Diabetes: A Reference Single-Center Cohort Study from Poland.
Kania, Michal; Mazur, Konrad; Terlecki, Michal; Matejko, Bartlomiej; Hohendorff, Jerzy; Chaykivska, Zlata; Fiema, Mateusz; Kopka, Marianna; Kostrzycka, Malgorzata; Wilk, Magdalena; Klupa, Tomasz; Witek, Przemyslaw; Katra, Barbara; Klocek, Marek; Rajzer, Marek; Malecki, Maciej T.
Afiliação
  • Kania M; Department of Metabolic Diseases and Diabetology, Jagiellonian University Medical College, Krakow, Poland.
  • Mazur K; University Hospital in Krakow, Krakow, Poland.
  • Terlecki M; University Hospital in Krakow, Krakow, Poland.
  • Matejko B; University Hospital in Krakow, Krakow, Poland.
  • Hohendorff J; Department of Cardiology, Interventional Electrocardiology and Arterial Hypertension, Jagiellonian University Medical College, Krakow, Poland.
  • Chaykivska Z; Department of Metabolic Diseases and Diabetology, Jagiellonian University Medical College, Krakow, Poland.
  • Fiema M; University Hospital in Krakow, Krakow, Poland.
  • Kopka M; Department of Metabolic Diseases and Diabetology, Jagiellonian University Medical College, Krakow, Poland.
  • Kostrzycka M; University Hospital in Krakow, Krakow, Poland.
  • Wilk M; University Hospital in Krakow, Krakow, Poland.
  • Klupa T; University Hospital in Krakow, Krakow, Poland.
  • Witek P; University Hospital in Krakow, Krakow, Poland.
  • Katra B; University Hospital in Krakow, Krakow, Poland.
  • Klocek M; Department of Metabolic Diseases and Diabetology, Jagiellonian University Medical College, Krakow, Poland.
  • Rajzer M; University Hospital in Krakow, Krakow, Poland.
  • Malecki MT; Department of Metabolic Diseases and Diabetology, Jagiellonian University Medical College, Krakow, Poland.
Int J Endocrinol ; 2023: 8700302, 2023.
Article em En | MEDLINE | ID: mdl-36844106
Background: Diabetes is a risk factor for a severe course of COVID-19. We evaluated the characteristics and risk factors associated with undesirable outcomes in diabetic patients (DPs) hospitalized due to COVID-19. Materials and Methods: The data analysis of patients admitted between March 6, 2020, and May 31, 2021, to the University Hospital in Krakow (Poland), a reference center for COVID-19, was performed. The data were gathered from their medical records. Results: A total number of 5191 patients were included, of which 2348 (45.2%) were women. The patients were at the median age of 64 (IQR: 51-74) years, and 1364 (26.3%) were DPs. DPs, compared to nondiabetics, were older (median age: 70 years, IQR: 62-77 vs. 62, IQR: 47-72, and p < 0.001) and had a similar gender distribution. The DP group had a higher mortality rate (26.2% vs. 15.7%, p < 0.001) and longer hospital stays (median: 15 days, IQR: 10-24 vs. 13, IQR: 9-20, and p < 0.001). DPs were admitted to the ICU more frequently (15.7% vs. 11.0%, p < 0.001) and required mechanical ventilation more often (15.5% vs. 11.3%, p < 0.001). In a multivariate logistic regression, factors associated with a higher risk of death were age >65 years, glycaemia >10 mmol/L, CRP and D-dimer level, prehospital insulin and loop diuretic use, presence of heart failure, and chronic kidney disease. Factors contributing to lower mortality were in-hospital use of statin, thiazide diuretic, and calcium channel blocker. Conclusion: In this large COVID-19 cohort, DPs constituted more than a quarter of hospitalized patients. The risk of death and other outcomes compared to nondiabetics was higher in this group. We identified a number of clinical, laboratory, and therapeutic variables associated with the risk of hospital death in DPs.

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Int J Endocrinol Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Polônia País de publicação: Egito

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Int J Endocrinol Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Polônia País de publicação: Egito