Ultrastructure of hyaline cartilage. 2. Recent developments in preparatory procedures of electron microscopy and immunocytochemistry for the classification of bone dysplasias.

Recent developments in preparatory procedures for electron microscopy and immunocytochemistry are presented as a background for the morphological diagnosis of bone dysplasia. With the new low temperature embedding techniques and the availability of monoclonal antibodies raised against the main matrix macromolecules, biopsies have proved to be an important complement to clinical and radiological workup and they may sometimes provide the final clue to the diagnosis.