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Optimization of carbazole carboxamide RORγt agonists: Challenges in improving the metabolic stability and maintaining the agonistic activity.
Sun, Nannan; Yu, Mingcheng; Jiang, Zhengyuan; Yang, Feng; Lu, Lixue; Xia, Yuehan; Zhao, Yunpeng; Huang, Yafei; Chen, Song; Chen, Shijie; Luo, Cheng; Wang, Yonghui; Xie, Qiong.
Afiliação
  • Sun N; Department of Medicinal Chemistry, School of Pharmacy, Fudan University, 826 Zhangheng Road, Pudong, Shanghai, 201203, China; Fudan Zhangjiang Institute, Shanghai, 201203, China; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 450001, China.
  • Yu M; Department of Medicinal Chemistry, School of Pharmacy, Fudan University, 826 Zhangheng Road, Pudong, Shanghai, 201203, China.
  • Jiang Z; Department of Medicinal Chemistry, School of Pharmacy, Fudan University, 826 Zhangheng Road, Pudong, Shanghai, 201203, China.
  • Yang F; Department of Medicinal Chemistry, School of Pharmacy, Fudan University, 826 Zhangheng Road, Pudong, Shanghai, 201203, China; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai, 201
  • Lu L; Department of Medicinal Chemistry, School of Pharmacy, Fudan University, 826 Zhangheng Road, Pudong, Shanghai, 201203, China.
  • Xia Y; Department of Medicinal Chemistry, School of Pharmacy, Fudan University, 826 Zhangheng Road, Pudong, Shanghai, 201203, China.
  • Zhao Y; Department of Medicinal Chemistry, School of Pharmacy, Fudan University, 826 Zhangheng Road, Pudong, Shanghai, 201203, China.
  • Huang Y; Department of Medicinal Chemistry, School of Pharmacy, Fudan University, 826 Zhangheng Road, Pudong, Shanghai, 201203, China.
  • Chen S; Department of Medicinal Chemistry, School of Pharmacy, Fudan University, 826 Zhangheng Road, Pudong, Shanghai, 201203, China.
  • Chen S; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai, 201203, China.
  • Luo C; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai, 201203, China.
  • Wang Y; Department of Medicinal Chemistry, School of Pharmacy, Fudan University, 826 Zhangheng Road, Pudong, Shanghai, 201203, China. Electronic address: yonghuiwang@fudan.edu.cn.
  • Xie Q; Department of Medicinal Chemistry, School of Pharmacy, Fudan University, 826 Zhangheng Road, Pudong, Shanghai, 201203, China; Fudan Zhangjiang Institute, Shanghai, 201203, China. Electronic address: qxie@fudan.edu.cn.
Eur J Med Chem ; 251: 115213, 2023 May 05.
Article em En | MEDLINE | ID: mdl-36905917
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carbazóis / Membro 3 do Grupo F da Subfamília 1 de Receptores Nucleares Limite: Animals Idioma: En Revista: Eur J Med Chem Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China País de publicação: França
Texto completo
Adicionar na Minha BVS
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PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carbazóis / Membro 3 do Grupo F da Subfamília 1 de Receptores Nucleares Limite: Animals Idioma: En Revista: Eur J Med Chem Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China País de publicação: França