Endogenous production of &#969;-3 polyunsaturated fatty acids mitigates cisplatin-induced myelosuppression by regulating NRF2-MDM2-p53 signaling pathway.

Xu, Qihua; Zhang, Zongmeng; Tang, Minyi; Xing, Chaofeng; Chen, Hansi; Zheng, Kexin; Zhao, Zhenggang; Zhou, Sujin; Zhao, Allan Zijian; Li, Fanghong; Mu, Yunping

Endogenous production of ω-3 polyunsaturated fatty acids mitigates cisplatin-induced myelosuppression by regulating NRF2-MDM2-p53 signaling pathway.

Xu, Qihua; Zhang, Zongmeng; Tang, Minyi; Xing, Chaofeng; Chen, Hansi; Zheng, Kexin; Zhao, Zhenggang; Zhou, Sujin; Zhao, Allan Zijian; Li, Fanghong; Mu, Yunping.

Afiliação

Xu Q; The School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, 510006, PR China.
Zhang Z; The School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, 510006, PR China.
Tang M; The School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, 510006, PR China.
Xing C; The School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, 510006, PR China.
Chen H; The School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, 510006, PR China.
Zheng K; The School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, 510006, PR China.
Zhao Z; The School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, 510006, PR China.
Zhou S; The School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, 510006, PR China.
Zhao AZ; The School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, 510006, PR China.
Li F; The School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, 510006, PR China. Electronic address: fli@gdut.edu.cn.
Mu Y; The School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, 510006, PR China. Electronic address: muyunping2018@gdut.edu.cn.

Free Radic Biol Med ; 201: 14-25, 2023 05 20.

Article em En | MEDLINE | ID: mdl-36906190

Assuntos

Cisplatino; Ácidos Graxos Ômega-3; Camundongos; Animais; Cisplatino/toxicidade; Fator 2 Relacionado a NF-E2/genética; Fator 2 Relacionado a NF-E2/metabolismo; Proteína Supressora de Tumor p53/genética; Proteína Supressora de Tumor p53/metabolismo; Antioxidantes/farmacologia; Ácidos Graxos Ômega-3/farmacologia; Ácidos Graxos Ômega-3/metabolismo; Camundongos Transgênicos; Transdução de Sinais

Palavras-chave

Cisplatin; Myelosuppression; NRF2-MDM2-p53; Oxidative damages; Transgenic mfat-1 mice; ω-3 polyunsaturated fatty acids

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ácidos Graxos Ômega-3 / Cisplatino Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Free Radic Biol Med Assunto da revista: BIOQUIMICA / MEDICINA Ano de publicação: 2023 Tipo de documento: Article País de publicação: Estados Unidos

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google