Exposure to non-persistent pesticides and sexual maturation of Spanish adolescent males.
Chemosphere
; 324: 138350, 2023 May.
Article
em En
| MEDLINE
| ID: mdl-36907483
ABSTRACT
BACKGROUND:
Several non-persistent pesticides are endocrine disrupting chemicals and may impact on sexual maturation.OBJECTIVE:
To examine the association between urinary biomarkers of non-persistent pesticides and sexual maturation in adolescent males in the Environment and Childhood (INMA) Project.METHODS:
The metabolites of several pesticides were measured in spot urine samples collected from 201 boys aged 14-17 years, including 3,5,6-trichloro-2-pyridinol (TCPy), metabolite of chlorpyrifos; 2-isopropyl-4-methyl-6-hydroxypyrimidine (IMPy), metabolite of diazinon; malathion diacid (MDA), metabolite of malathion; diethyl thiophosphate (DETP) and diethyl dithiophosphate, non-specific metabolites of organophosphates; 3-phenoxybenzoic acid (3-PBA) and dimethyl cyclopropane carboxylic acid, metabolites of pyrethroids; 1-naphthol (1-NPL), metabolite of carbaryl; and ethylene thiourea (ETU), metabolite of dithiocarbamate fungicides. Sexual maturation was assessed using Tanner stages, self-reported Pubertal Development Scale, and testicular volume (TV). Multivariate logistic regression was employed to examine associations between urinary pesticide metabolites and the odds of being in Tanner stage 5 of genital development (G5) or pubic hair growth (PH5); stage ≥4 of overall pubertal development, gonadarche, and adrenarche; or having mature TV (≥25 mL).RESULTS:
DETP concentrations>75th percentile (P75) were associated with lower odds of being in stage G5 (OR = 0.27; 95% CI = 0.10-0.70), detectable TCPy with lower odds of gonadal stage≥4 (OR = 0.50; 95% CI = 0.26-0.96), and intermediate detectable MDA concentrations (Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Praguicidas
/
Clorpirifos
Limite:
Adolescent
/
Child
/
Humans
/
Male
Idioma:
En
Revista:
Chemosphere
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Espanha