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Assessing the Role of Past Depression in Patients with Mild Cognitive Impairment, with and without Biomarkers for Alzheimer's Disease.
Golas, Angela C; Salwierz, Patrick; Rajji, Tarek K; Bowie, Christopher R; Butters, Meryl A; Fischer, Corinne E; Flint, Alastair J; Herrmann, Nathan; Mah, Linda; Mulsant, Benoit H; Pollock, Bruce G; Taghdiri, Foad; Wang, Wei; Tartaglia, M Carmela.
Afiliação
  • Golas AC; Centre for Addiction and Mental Health, Toronto, ON, Canada.
  • Salwierz P; Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
  • Rajji TK; Centre for Addiction and Mental Health, Toronto, ON, Canada.
  • Bowie CR; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.
  • Butters MA; Division of Neurology, Department of Medicine, University of Toronto, Toronto, ON, Canada.
  • Fischer CE; Centre for Addiction and Mental Health, Toronto, ON, Canada.
  • Flint AJ; Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
  • Herrmann N; Toronto Dementia Research Alliance, University of Toronto, Toronto, ON, Canada.
  • Mah L; Centre for Addiction and Mental Health, Toronto, ON, Canada.
  • Mulsant BH; Department of Psychology, Queen's University, Kingston, ON, Canada.
  • Pollock BG; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
  • Taghdiri F; Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
  • Wang W; Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, ON, Canada.
  • Tartaglia MC; Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
J Alzheimers Dis ; 92(4): 1219-1227, 2023.
Article em En | MEDLINE | ID: mdl-36911939
ABSTRACT
Major depressive disorder (MDD) is a risk factor for Alzheimer's disease (AD). Cerebrovascular disease (CVD) is implicated in MDD and AD. Our study compared participants with AD positive and negative cerebrospinal fluid (CSF) biomarkers on neuropsychological performance, remitted MDD status, and CVD burden. Next, we compared AD-CSF biomarkers and white matter hyperintensities (WMH) burden among three groups mild cognitive impairment (MCI) (n = 12), MCI with remitted MDD (MDD+MCI) (n = 12), and remitted MDD alone (MDD) (n = 7). Few participants (18%) with MCI+MDD exhibited AD(+) biomarkers. Nearly all participants had moderate-severe WMH. WMH may contribute to cognitive impairment or depression in MCI patients with AD(-) biomarkers.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Cardiovasculares / Transtorno Depressivo Maior / Doença de Alzheimer / Disfunção Cognitiva Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Revista: J Alzheimers Dis Assunto da revista: GERIATRIA / NEUROLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Canadá
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Cardiovasculares / Transtorno Depressivo Maior / Doença de Alzheimer / Disfunção Cognitiva Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Revista: J Alzheimers Dis Assunto da revista: GERIATRIA / NEUROLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Canadá