HIV-1 remission and possible cure in a woman after haplo-cord blood transplant.
Cell
; 186(6): 1115-1126.e8, 2023 03 16.
Article
em En
| MEDLINE
| ID: mdl-36931242
ABSTRACT
Previously, two men were cured of HIV-1 through CCR5Δ32 homozygous (CCR5Δ32/Δ32) allogeneic adult stem cell transplant. We report the first remission and possible HIV-1 cure in a mixed-race woman who received a CCR5Δ32/Δ32 haplo-cord transplant (cord blood cells combined with haploidentical stem cells from an adult) to treat acute myeloid leukemia (AML). Peripheral blood chimerism was 100% CCR5Δ32/Δ32 cord blood by week 14 post-transplant and persisted through 4.8 years of follow-up. Immune reconstitution was associated with (1) loss of detectable replication-competent HIV-1 reservoirs, (2) loss of HIV-1-specific immune responses, (3) in vitro resistance to X4 and R5 laboratory variants, including pre-transplant autologous latent reservoir isolates, and (4) 18 months of HIV-1 control with aviremia, off antiretroviral therapy, starting at 37 months post-transplant. CCR5Δ32/Δ32 haplo-cord transplant achieved remission and a possible HIV-1 cure for a person of diverse ancestry, living with HIV-1, who required a stem cell transplant for acute leukemia.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Leucemia Mieloide Aguda
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Infecções por HIV
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HIV-1
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Transplante de Células-Tronco Hematopoéticas
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Transplante de Células-Tronco de Sangue do Cordão Umbilical
Limite:
Adult
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Female
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Humans
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Male
Idioma:
En
Revista:
Cell
Ano de publicação:
2023
Tipo de documento:
Article