Clinical risk factors at 3 months of age for the development of bronchial asthma at 36 months of age.
Pediatr Int
; 65(1): e15530, 2023.
Article
em En
| MEDLINE
| ID: mdl-36932701
ABSTRACT
BACKGROUND:
We examined the associations between factors evident at the routine 3-month well-child visit (WCV) and the risk of developing 36-month parent-reported physician-diagnosed bronchial asthma (BA).METHODS:
This longitudinal study was conducted in Nagoya City, Japan, and included 40,242 children who qualified for the 3-month WCVs in the city between April 1, 2016 and March 31, 2018. In total, 22,052 (54.8%) questionnaires linked to their 36-month WCVs were analyzed.RESULTS:
The prevalence of BA was 4.5%. The multivariable Poisson regression model identified male sex (adjusted risk ratio [aRR], 1.59; 95% confidence interval [CI] 1.40-1.81), born in autumn (aRR, 1.30; 95% CI 1.09-1.55), having at least one sibling (aRR, 1.31; 95% CI 1.15-1.49), wheeze history before 3-month WCVs, with clinic/hospital visit aRR, 1.99; 95% CI 1.53-2.56; hospitalization aRR, 2.99; 95% CI 2.09-4.12, eczema with itch (aRR, 1.51; 95% CI 1.27-1.80), paternal history of BA (aRR, 1.98; 95% CI 1.66-2.34), maternal history of BA (aRR, 2.11; 95% CI 1.77-2.49), and rearing pets with fur (aRR, 1.35; 95% CI 1.15-1.58) were independent risk factors for BA at 36 months of age. The combination of severe wheeze history (with clinic/hospital visit or hospitalization) and maternal and paternal BA could identify high-risk infants whose prevalence of BA was 20%.CONCLUSIONS:
The combined assessment of important clinical factors enabled us to identify high-risk infants set to derive optimal benefit from health guidance provided to the parent or caregiver of the child or infant at WCVs.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Asma
/
Eczema
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Guideline
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Child, preschool
/
Humans
/
Infant
/
Male
Idioma:
En
Revista:
Pediatr Int
Assunto da revista:
PEDIATRIA
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Japão