Serum metabolomics assessment of etiological processes predisposing ketosis in water buffalo during early lactation.
J Dairy Sci
; 106(5): 3465-3476, 2023 May.
Article
em En
| MEDLINE
| ID: mdl-36935234
ABSTRACT
Metabolic disorders as ketosis are manifestations of the animal's inability to manage the increase in energy requirement during early lactation. Generally, buffaloes show a different response to higher metabolic demands than other ruminants with a lower incidence of metabolic problems, although ketosis is one of the major diseases that may decrease the productivity in buffaloes. The aim of this study was to characterize the metabolic profile of Mediterranean buffaloes (MB) associated with 2 different levels of ß-hydroxybutyrate (BHB). Sixty-two MB within 50 days in milk (DIM) were enrolled and divided into 2 groups according to serum BHB concentration healthy group (37 MB; BHB <0.70 mmol/L; body condition score 5.00; parity 3.78; and DIM 30.70) and group at risk of hyperketonemia (25 MB; BHB ≥0.70 mmol/L; body condition score 4.50; parity 3.76; and DIM 33.20). The statistical analysis was conducted by one-way ANOVA and unpaired 2-sample Wilcoxon tests. Fifty-seven metabolites were identified and among them, 12 were significant or tended to be significant. These metabolites were related to different metabolic changes such as mobilization of body resources, ruminal fermentations, urea cycle, thyroid hormone synthesis, inflammation, and oxidative stress status. These findings are suggestive of metabolic changes related to subclinical ketosis status that should be further investigated to better characterize this disease in the MB.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças dos Bovinos
/
Cetose
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
Limite:
Animals
/
Pregnancy
Idioma:
En
Revista:
J Dairy Sci
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Itália