Rational genome and metabolic engineering of Candida viswanathii by split CRISPR to produce hundred grams of dodecanedioic acid.

Pham, Nam Ngoc; Chang, Chin-Wei; Chang, Yi-Hao; Tu, Yi; Chou, June-Yen; Wang, Hsing-Yun; Hu, Yu-Chen

Pham, Nam Ngoc; Chang, Chin-Wei; Chang, Yi-Hao; Tu, Yi; Chou, June-Yen; Wang, Hsing-Yun; Hu, Yu-Chen.

Afiliação

Pham NN; Department of Chemical Engineering, National Tsing Hua University, Hsinchu, Taiwan.
Chang CW; Department of Chemical Engineering, National Tsing Hua University, Hsinchu, Taiwan.
Chang YH; Department of Chemical Engineering, National Tsing Hua University, Hsinchu, Taiwan.
Tu Y; Department of Life Science, National Taiwan University, Taipei, Taiwan.
Chou JY; Innovation and R&D Division, Chang Chun Group, Taipei, Taiwan; Dairen Chemical Corp, Taipei, Taiwan.
Wang HY; Dairen Chemical Corp, Taipei, Taiwan.
Hu YC; Department of Chemical Engineering, National Tsing Hua University, Hsinchu, Taiwan; Frontier Research Center on Fundamental and Applied Sciences of Matters, National Tsing Hua University, Hsinchu, Taiwan. Electronic address: yuchen@che.nthu.edu.tw.

Metab Eng ; 77: 76-88, 2023 05.

Article em En | MEDLINE | ID: mdl-36948241

Assuntos

Candida; Engenharia Metabólica; Candida/genética; Candida/metabolismo; Ácidos Dicarboxílicos/metabolismo; Sistemas CRISPR-Cas

Palavras-chave

C. viswanathii; CPRb; CYP52A19; Dodecanedioic acid; POS5; Split CRISPR

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Candida / Engenharia Metabólica Tipo de estudo: Prognostic_studies Idioma: En Revista: Metab Eng Assunto da revista: ENGENHARIA BIOMEDICA / METABOLISMO Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Taiwan País de publicação: Bélgica

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