Bazedoxifene attenuates intestinal injury in sepsis by suppressing the NF-&#954;B/NLRP3 signaling pathways.

Zhang, Xiao; Ning, Wei; Gao, Ge; Zhou, Yong; Duan, Xiang-Bing; Li, Xin; Li, Dai; Guo, Ren

Bazedoxifene attenuates intestinal injury in sepsis by suppressing the NF-κB/NLRP3 signaling pathways.

Zhang, Xiao; Ning, Wei; Gao, Ge; Zhou, Yong; Duan, Xiang-Bing; Li, Xin; Li, Dai; Guo, Ren.

Afiliação

Zhang X; Phase I Clinical Research Center, Xiangya Hospital, Central South University, Changsha, 410005, China; Laboratory Department, The Third Xiangya Hospital, Central South University, Changsha, 410013, China.
Ning W; Phase I Clinical Research Center, Xiangya Hospital, Central South University, Changsha, 410005, China; Laboratory Department, The Third Xiangya Hospital, Central South University, Changsha, 410013, China.
Gao G; Laboratory Department, The Third Xiangya Hospital, Central South University, Changsha, 410013, China.
Zhou Y; Department of Physiology, School of Basic Medical Science, Central South University, Changsha, 410078, China.
Duan XB; Laboratory Department, The Third Xiangya Hospital, Central South University, Changsha, 410013, China.
Li X; Laboratory Department, The Third Xiangya Hospital, Central South University, Changsha, 410013, China.
Li D; Phase I Clinical Research Center, Xiangya Hospital, Central South University, Changsha, 410005, China. Electronic address: lidai01@csu.edu.cn.
Guo R; Department of Pharmacy, The Third Xiangya Hospital, Central South University, Changsha, 410013, China. Electronic address: pharmguor@csu.edu.cn.

Eur J Pharmacol ; 947: 175681, 2023 May 15.

Article em En | MEDLINE | ID: mdl-36965746

Assuntos

NF-kappa B; Sepse; Camundongos; Animais; NF-kappa B/metabolismo; Proteína 3 que Contém Domínio de Pirina da Família NLR/metabolismo; Lipopolissacarídeos/farmacologia; Transdução de Sinais; Inflamassomos/metabolismo; Inflamação; Sepse/complicações; Sepse/tratamento farmacológico

Palavras-chave

Bazedoxifene; Inflammation; Intestinal injury; NF-κB; NLRP3 inflammasome; Sepsis

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: NF-kappa B / Sepse Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Eur J Pharmacol Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China País de publicação: Holanda

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google