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Immune tolerance breakdown in inborn errors of immunity: Paving the way to novel therapeutic approaches.
Giardino, Giuliana; Romano, Roberta; Lougaris, Vassilios; Castagnoli, Riccardo; Cillo, Francesca; Leonardi, Lucia; La Torre, Francesco; Soresina, Annarosa; Federici, Silvia; Cancrini, Caterina; Pacillo, Lucia; Toriello, Elisabetta; Cinicola, Bianca Laura; Corrente, Stefania; Volpi, Stefano; Marseglia, Gian Luigi; Pignata, Claudio; Cardinale, Fabio.
Afiliação
  • Giardino G; Pediatric Section, Department of Translational Medical Sciences, Federico II University, Naples, Italy. Electronic address: giuliana.giardino@unina.it.
  • Romano R; Pediatric Section, Department of Translational Medical Sciences, Federico II University, Naples, Italy.
  • Lougaris V; Department of Clinical and Experimental Sciences, Pediatrics Clinic and Institute for Molecular Medicine A. Nocivelli, University of Brescia and ASST-Spedali Civili di Brescia, Brescia, Italy.
  • Castagnoli R; Department of Pediatrics, Pediatric Clinic, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy.
  • Cillo F; Pediatric Section, Department of Translational Medical Sciences, Federico II University, Naples, Italy.
  • Leonardi L; Department of Maternal Infantile and Urological Sciences, Sapienza University of Rome, Rome, Italy.
  • La Torre F; Department of Pediatrics, Giovanni XXIII Pediatric Hospital, University of Bari, Bari, Italy.
  • Soresina A; Unit of Pediatric Immunology, Pediatrics Clinic, University of Brescia, ASST Spedali Civili Brescia, Brescia, Italy.
  • Federici S; Division of Rheumatology, IRCCS, Ospedale Pediatrico Bambino Gesù, Rome, Italy.
  • Cancrini C; Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy; Research Unit of Primary Immunodeficiencies, IRCCS Bambino Gesù Children's Hospital, Rome, Italy.
  • Pacillo L; Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy; Research Unit of Primary Immunodeficiencies, IRCCS Bambino Gesù Children's Hospital, Rome, Italy.
  • Toriello E; Pediatric Section, Department of Translational Medical Sciences, Federico II University, Naples, Italy.
  • Cinicola BL; Department of Maternal Infantile and Urological Sciences, Sapienza University of Rome, Rome, Italy.
  • Corrente S; Division of Pediatrics, S. Camillo-Forlanini Hospital, Rome, Italy.
  • Volpi S; Center for Autoinflammatory Diseases and Immunodeficiency, IRCCS Istituto Giannina Gaslini, Università degli Studi di Genova, Genoa, Italy.
  • Marseglia GL; Department of Pediatrics, Pediatric Clinic, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy.
  • Pignata C; Pediatric Section, Department of Translational Medical Sciences, Federico II University, Naples, Italy.
  • Cardinale F; Department of Pediatrics, Giovanni XXIII Pediatric Hospital, University of Bari, Bari, Italy.
Clin Immunol ; 251: 109302, 2023 06.
Article em En | MEDLINE | ID: mdl-36967025
ABSTRACT
Up to 25% of the patients with inborn errors of immunity (IEI) also exhibit immunodysregulatory features. The association of immune dysregulation and immunodeficiency may be explained by different mechanisms. The understanding of mechanisms underlying immune dysregulation in IEI has paved the way for the development of targeted treatments. In this review article, we will summarize the mechanisms of immune tolerance breakdown and the targeted therapeutic approaches to immune dysregulation in IEI.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tolerância Imunológica / Doenças do Sistema Imunitário Limite: Humans Idioma: En Revista: Clin Immunol Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tolerância Imunológica / Doenças do Sistema Imunitário Limite: Humans Idioma: En Revista: Clin Immunol Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2023 Tipo de documento: Article