Brain Derived Neurotrophic Factor Interacts with White Matter Hyperintensities to Influence Processing Speed and Hippocampal Volume in Older Adults.
J Alzheimers Dis
; 93(1): 141-149, 2023.
Article
em En
| MEDLINE
| ID: mdl-36970903
ABSTRACT
BACKGROUND:
Brain-derived neurotrophic factor (BDNF) is a neurotrophin that plays an important role in regulating synaptic activity and plasticity.OBJECTIVE:
Given that type-2 diabetes (T2DM) increases the risk of cognitive decline, and studies have suggested lower BDNF levels may be a risk factor of diabetic neurovascular complications, we sought to investigate total white matter hyperintensities (WMH) as a moderator of the effect of BDNF on hippocampal volume and cognition.METHODS:
Older adults without dementia from the Alzheimer's Disease Neuroimaging Initiative (Nâ=â454 including 49 with T2DM and 405 without diabetes) underwent neuropsychological evaluation, magnetic resonance imaging to quantify hippocampal and WMH volumes, and blood draw to assess BDNF.RESULTS:
Adjusting for age, sex, and APOE É4 carrier status, there was a significant interaction between total WMH and BDNF on bilateral hippocampal volume in the non-T2DM group (tâ=â2.63, pâ=â0.009). Examination of main effect models with a dichotomous high/low BNDF group revealed a significant main effect for low BDNF (tâ=â-4.98, pâ<â0.001), such that as WMH increased, bilateral hippocampal volume decreased. There was also a significant interaction between total WMH and BDNF on processing speed in the non-T2DM group (tâ=â2.91, pâ=â0.004). There was a significant main effect for low BDNF (tâ=â-3.55, pâ<â0.001) such that as WMH increased, processing speed decreased. The interactions were not significant in the T2DM group.CONCLUSION:
These results further elucidate the protective role that BDNF plays on cognition, as well as the cognitive effects of WMH.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Disfunção Cognitiva
/
Substância Branca
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Limite:
Aged
/
Humans
Idioma:
En
Revista:
J Alzheimers Dis
Assunto da revista:
GERIATRIA
/
NEUROLOGIA
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Estados Unidos