Monoterpenoid Epoxidiol Ameliorates the Pathological Phenotypes of the Rotenone-Induced Parkinson's Disease Model by Alleviating Mitochondrial Dysfunction.

Aleksandrova, Yulia; Chaprov, Kirill; Podturkina, Alexandra; Ardashov, Oleg; Yandulova, Ekaterina; Volcho, Konstantin; Salakhutdinov, Nariman; Neganova, Margarita

Aleksandrova, Yulia; Chaprov, Kirill; Podturkina, Alexandra; Ardashov, Oleg; Yandulova, Ekaterina; Volcho, Konstantin; Salakhutdinov, Nariman; Neganova, Margarita.

Afiliação

Aleksandrova Y; Institute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Severnij Pr. 1, Chernogolovka 142432, Russia.
Chaprov K; Institute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Severnij Pr. 1, Chernogolovka 142432, Russia.
Podturkina A; Department of Medicinal Chemistry, N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences, Lavrentiev Ave., 9, Novosibirsk 630090, Russia.
Ardashov O; Department of Medicinal Chemistry, N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences, Lavrentiev Ave., 9, Novosibirsk 630090, Russia.
Yandulova E; Institute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Severnij Pr. 1, Chernogolovka 142432, Russia.
Volcho K; Department of Medicinal Chemistry, N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences, Lavrentiev Ave., 9, Novosibirsk 630090, Russia.
Salakhutdinov N; Department of Medicinal Chemistry, N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences, Lavrentiev Ave., 9, Novosibirsk 630090, Russia.
Neganova M; Institute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Severnij Pr. 1, Chernogolovka 142432, Russia.

Int J Mol Sci ; 24(6)2023 Mar 19.

Article em En | MEDLINE | ID: mdl-36982914

Assuntos

Neuroblastoma; Doenças Neurodegenerativas; Fármacos Neuroprotetores; Doença de Parkinson; Animais; Humanos; Doença de Parkinson/tratamento farmacológico; Doença de Parkinson/etiologia; Doença de Parkinson/metabolismo; Rotenona/toxicidade; Rotenona/metabolismo; Monoterpenos/metabolismo; Doenças Neurodegenerativas/metabolismo; Linhagem Celular Tumoral; Neuroblastoma/metabolismo; Espécies Reativas de Oxigênio/metabolismo; Mitocôndrias/metabolismo; Fenótipo; Fármacos Neuroprotetores/farmacologia; Fármacos Neuroprotetores/uso terapêutico; Fármacos Neuroprotetores/metabolismo

Palavras-chave

Parkinson's disease; ROS; disease-modifying therapy; epoxidiol; mitochondrial dysfunction; neurodegenerative diseases; rotenone

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Fármacos Neuroprotetores / Doenças Neurodegenerativas / Neuroblastoma Tipo de estudo: Etiology_studies Limite: Animals / Humans Idioma: En Revista: Int J Mol Sci Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Federação Russa País de publicação: Suíça

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google