[Infections in patients with acute myeloid leukemia]. / Infektionen bei Patient*innen mit Akuter Myeloischer Leukämie.
Dtsch Med Wochenschr
; 148(8): 467-473, 2023 04.
Article
em De
| MEDLINE
| ID: mdl-36990119
ABSTRACT
Infections represent one of the most frequent complications during therapy of acute myeloid leukemia (AML). In addition to associated prolonged phases of neutropenia, damage to the mucosal barrier by cytotoxic agents favors infections caused by endogenous pathogens. The source often remains unknown with bacteremia being the most common evidence of infection. Infections with gram-positive bacteria predominate, however, infections with gram-negative bacteria more often lead to sepsis and death. Due to prolonged neutropenia, patients with AML are furthermore at risk for invasive fungal infections. Viruses, on the other hand, are rarely the cause of neutropenic fever. Because of the limited inflammatory response in neutropenic patients, fever is often the only sign of infection and therefore always represents a hematologic emergency. Prompt diagnosis and initiation of an adequate anti-infective therapy are critical to avoid progression to sepsis and possibly death.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Leucemia Mieloide Aguda
/
Bacteriemia
/
Sepse
/
Neutropenia
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
Limite:
Humans
Idioma:
De
Revista:
Dtsch Med Wochenschr
Ano de publicação:
2023
Tipo de documento:
Article