Arresting microbiome development limits immune system maturation and resistance to infection in mice.

Lubin, Jean-Bernard; Green, Jamal; Maddux, Sarah; Denu, Lidiya; Duranova, Tereza; Lanza, Matthew; Wynosky-Dolfi, Meghan; Flores, Julia N; Grimes, Logan P; Brodsky, Igor E; Planet, Paul J; Silverman, Michael A

Lubin, Jean-Bernard; Green, Jamal; Maddux, Sarah; Denu, Lidiya; Duranova, Tereza; Lanza, Matthew; Wynosky-Dolfi, Meghan; Flores, Julia N; Grimes, Logan P; Brodsky, Igor E; Planet, Paul J; Silverman, Michael A.

Afiliação

Lubin JB; Division of Infectious Disease, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Green J; Division of Infectious Disease, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Perlman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Maddux S; Division of Infectious Disease, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Denu L; Division of Infectious Disease, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Duranova T; Division of Infectious Disease, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Lanza M; Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA.
Wynosky-Dolfi M; Immunology Research Unit, GlaxoSmithKline, Collegeville, PA, USA.
Flores JN; Division of Infectious Disease, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Grimes LP; Division of Infectious Disease, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Brodsky IE; Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA; Institute for Immunology, IFI, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Planet PJ; Division of Infectious Disease, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Perlman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Ph
Silverman MA; Division of Infectious Disease, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Perlman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Immunology Research Unit, GlaxoSmithKline, Collegeville, PA, USA; Department of Microbi

Cell Host Microbe ; 31(4): 554-570.e7, 2023 04 12.

Article em En | MEDLINE | ID: mdl-36996818

Assuntos

Microbioma Gastrointestinal; Microbiota; Lactente; Adulto; Animais; Humanos; Camundongos; Criança; Vida Livre de Germes; Desmame; Sistema Imunitário

Palavras-chave

IgA; Salmonella; early life; germ-free; gnotobiotic; immune system development; microbiome; regulatory T cell; weaning

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Microbiota / Microbioma Gastrointestinal Tipo de estudo: Prognostic_studies Limite: Adult / Animals / Child / Humans / Infant Idioma: En Revista: Cell Host Microbe Assunto da revista: MICROBIOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos

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