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Cytotoxic cis-ruthenium(III) bis(amidine) complexes.
Liu, Tao; Pan, Chen; Shi, Huatian; Huang, Tao; Huang, Yong-Liang; Deng, Yang-Yang; Ni, Wen-Xiu; Man, Wai-Lun.
Afiliação
  • Liu T; Department of Medicinal Chemistry, Shantou University Medical College, Shantou, Guangdong, 515041, P.R. China. wxni@stu.edu.hk.
  • Pan C; Department of Medicinal Chemistry, Shantou University Medical College, Shantou, Guangdong, 515041, P.R. China. wxni@stu.edu.hk.
  • Shi H; Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong, P.R. China. wlman118@hkbu.edu.hk.
  • Huang T; Department of Medicinal Chemistry, Shantou University Medical College, Shantou, Guangdong, 515041, P.R. China. wxni@stu.edu.hk.
  • Huang YL; Department of Medicinal Chemistry, Shantou University Medical College, Shantou, Guangdong, 515041, P.R. China. wxni@stu.edu.hk.
  • Deng YY; Department of Medicinal Chemistry, Shantou University Medical College, Shantou, Guangdong, 515041, P.R. China. wxni@stu.edu.hk.
  • Ni WX; Department of Medicinal Chemistry, Shantou University Medical College, Shantou, Guangdong, 515041, P.R. China. wxni@stu.edu.hk.
  • Man WL; Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong, P.R. China. wlman118@hkbu.edu.hk.
Dalton Trans ; 52(25): 8540-8548, 2023 Jun 27.
Article em En | MEDLINE | ID: mdl-37000490
In chemotherapy, the search for ruthenium compounds as alternatives to platinum compounds is proposed because of their unique properties. However, the geometry effect of ruthenium complexes is sparely investigated. In this paper, we report the synthesis of a series of bis(acetylacetonato)ruthenium(III) complexes bearing two amidines (1-) in a cis configuration. These complexes are highly cytotoxic against various cancer cell lines, including a cisplatin-resistant cell line. In vitro studies suggested that the representative complex can induce cell cycle G0/G1 phase arrest, decrease the mitochondrial membrane potential, elevate the intracellular reactive oxygen species level, and cause DNA damage and caspase-mediated mitochondrial pathway apoptosis in NCI-H460 cells. In vivo, it can effectively inhibit tumor xenograft growth in nude mouse models with no body weight loss. In combination with the reported trans-bis(amidine)ruthenium(III) complexes, we found that ruthenium(III) bis(amidine) complexes could be cytotoxic in both trans and cis geometries, which is in contrast to platinum-based compounds.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Rutênio / Complexos de Coordenação / Neoplasias / Antineoplásicos Limite: Animals / Humans Idioma: En Revista: Dalton Trans Assunto da revista: QUIMICA Ano de publicação: 2023 Tipo de documento: Article País de publicação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Rutênio / Complexos de Coordenação / Neoplasias / Antineoplásicos Limite: Animals / Humans Idioma: En Revista: Dalton Trans Assunto da revista: QUIMICA Ano de publicação: 2023 Tipo de documento: Article País de publicação: Reino Unido