The prognostic role of whole-body volumetric 68 GA-DOTATATE PET/computed tomography parameters in patients with gastroenteropancreatic neuroendocrine tumor treated with 177 LU-DOTATATE.
Nucl Med Commun
; 44(6): 509-517, 2023 Jun 01.
Article
em En
| MEDLINE
| ID: mdl-37038931
ABSTRACT
OBJECTIVE:
The aim of this study is to evaluate the prognostic role of Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 and quantitative 68 Ga-DOTATATE PET/computed tomography parameters such as maximum standardized uptake value (SUVmax), mean SUV (SUVmean), DOTATATE tumor volume (DTV), total lesion DOTATATE (TLD) in patients with gastroenteropancreatic neuroendocrine tumors (GEP-NETs) treated with 177 Lu-DOTATATE. MATERIAL ANDMETHOD:
Our retrospective study included 21 patients with GEP-NETs treated with 177 Lu-DOTATATE between January 2017 and January 2022. SUVmax, SUVmean, SUVmax/spleenSUVmax (SUVmax/Sx), DTV, TLD, SUVmean/spleenSUVmean (SUVmean/Sm), TLD/Sm values were calculated and recorded for all patients before and after 177 Lu-DOTATATE treatment.RESULTS:
A total of 319 metastases were detected in the patients included in the study, and a total of 68 target lesions were selected. In univariant Cox regression analysis, TLD/Sm percent change (∆TLD/Sm) was found to be statistically significant on overall survival (OS) ( P â =â 0.044). The 3-year survival in nonresponders was 50% ( P â =â 0.034) based on ∆SUVmax/Sx values, 50% ( P â =â 0.002) based on RECIST values, 50% based on ∆TDTVâ +â new lesion values ( P â =â 0.033), and according to ∆TTLDâ +â new lesion values, it was 66% ( P â =â 0.030).CONCLUSION:
In our study, we showed that SUVmax/Sx, RECIST, ∆TDTVâ + new lesion, and ∆TTLDâ + new lesion parameters can predict OS in the evaluation of response to treatment.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Compostos Organometálicos
/
Tumores Neuroendócrinos
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
Nucl Med Commun
Ano de publicação:
2023
Tipo de documento:
Article