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New Generation of sGC Stimulators: Discovery of Imidazo[1,2-a]pyridine Carboxamide BAY 1165747 (BAY-747), a Long-Acting Soluble Guanylate Cyclase Stimulator for the Treatment of Resistant Hypertension.
Vakalopoulos, Alexandros; Wunder, Frank; Hartung, Ingo V; Redlich, Gorden; Jautelat, Rolf; Buchgraber, Philipp; Hassfeld, Jorma; Gromov, Alexey V; Lindner, Niels; Bierer, Donald; Gries, Jörg; Kroh, Walter; Paulsen, Holger; Mittendorf, Joachim; Lang, Dieter; Becker-Pelster, Eva; Brockschnieder, Damian; Geiss, Volker; Li, Volkhart; Straub, Alexander; Knorr, Andreas; Mondritzki, Thomas; Trübel, Hubert; Raschke, Marian; Schaefer, Martina; Thomas, Dirk; Sandner, Peter; Stasch, Johannes-Peter; Follmann, Markus.
Afiliação
  • Vakalopoulos A; Pharmaceuticals, Research and Development, Bayer AG, Aprather Weg 18a, 42113 Wuppertal, Germany.
  • Wunder F; Pharmaceuticals, Research and Development, Bayer AG, Aprather Weg 18a, 42113 Wuppertal, Germany.
  • Hartung IV; Pharmaceuticals, Research and Development, Bayer AG, Aprather Weg 18a, 42113 Wuppertal, Germany.
  • Redlich G; Pharmaceuticals, Research and Development, Bayer AG, Aprather Weg 18a, 42113 Wuppertal, Germany.
  • Jautelat R; Pharmaceuticals, Research and Development, Bayer AG, Aprather Weg 18a, 42113 Wuppertal, Germany.
  • Buchgraber P; Pharmaceuticals, Research and Development, Bayer AG, Aprather Weg 18a, 42113 Wuppertal, Germany.
  • Hassfeld J; Pharmaceuticals, Research and Development, Bayer AG, Aprather Weg 18a, 42113 Wuppertal, Germany.
  • Gromov AV; Pharmaceuticals, Research and Development, Bayer AG, Aprather Weg 18a, 42113 Wuppertal, Germany.
  • Lindner N; Pharmaceuticals, Research and Development, Bayer AG, Aprather Weg 18a, 42113 Wuppertal, Germany.
  • Bierer D; Pharmaceuticals, Research and Development, Bayer AG, Aprather Weg 18a, 42113 Wuppertal, Germany.
  • Gries J; Pharmaceuticals, Research and Development, Bayer AG, Aprather Weg 18a, 42113 Wuppertal, Germany.
  • Kroh W; Pharmaceuticals, Research and Development, Bayer AG, Aprather Weg 18a, 42113 Wuppertal, Germany.
  • Paulsen H; Pharmaceuticals, Research and Development, Bayer AG, Aprather Weg 18a, 42113 Wuppertal, Germany.
  • Mittendorf J; Pharmaceuticals, Research and Development, Bayer AG, Aprather Weg 18a, 42113 Wuppertal, Germany.
  • Lang D; Pharmaceuticals, Research and Development, Bayer AG, Aprather Weg 18a, 42113 Wuppertal, Germany.
  • Becker-Pelster E; Pharmaceuticals, Research and Development, Bayer AG, Aprather Weg 18a, 42113 Wuppertal, Germany.
  • Brockschnieder D; Pharmaceuticals, Research and Development, Bayer AG, Aprather Weg 18a, 42113 Wuppertal, Germany.
  • Geiss V; Pharmaceuticals, Research and Development, Bayer AG, Aprather Weg 18a, 42113 Wuppertal, Germany.
  • Li V; Pharmaceuticals, Research and Development, Bayer AG, Aprather Weg 18a, 42113 Wuppertal, Germany.
  • Straub A; Pharmaceuticals, Research and Development, Bayer AG, Aprather Weg 18a, 42113 Wuppertal, Germany.
  • Knorr A; Pharmaceuticals, Research and Development, Bayer AG, Aprather Weg 18a, 42113 Wuppertal, Germany.
  • Mondritzki T; Pharmaceuticals, Research and Development, Bayer AG, Aprather Weg 18a, 42113 Wuppertal, Germany.
  • Trübel H; University of Witten/Herdecke, 58455 Witten, Germany.
  • Raschke M; Pharmaceuticals, Research and Development, Bayer AG, Aprather Weg 18a, 42113 Wuppertal, Germany.
  • Schaefer M; University of Witten/Herdecke, 58455 Witten, Germany.
  • Thomas D; Pharmaceuticals, Research and Development, Bayer AG, Aprather Weg 18a, 42113 Wuppertal, Germany.
  • Sandner P; Pharmaceuticals, Research and Development, Bayer AG, Aprather Weg 18a, 42113 Wuppertal, Germany.
  • Stasch JP; Lead Discovery, Nuvisan ICB GmbH, Muellerstrasse 178, 13353 Berlin, Germany.
  • Follmann M; Pharmaceuticals, Research and Development, Bayer AG, Aprather Weg 18a, 42113 Wuppertal, Germany.
J Med Chem ; 66(11): 7280-7303, 2023 06 08.
Article em En | MEDLINE | ID: mdl-37040336
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Guanilato Ciclase / Hipertensão Limite: Humans Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Alemanha País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Guanilato Ciclase / Hipertensão Limite: Humans Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Alemanha País de publicação: Estados Unidos