Characterization of Complexes between Imidacloprid and ß-Cyclodextrin: Evaluation of the Toxic Activity in Algae and Rotifers.
Molecules
; 28(7)2023 Mar 29.
Article
em En
| MEDLINE
| ID: mdl-37049814
ABSTRACT
The development of new formulations can be driven by the knowledge of host-guest complexes using cyclodextrins which have the ability to include guest molecules within their hydrophobic cavities, improving the physicochemical properties of the guest. To rationally explore new pesticide formulations, the effects of cyclodextrins on the properties of such guest molecules need to be explored. Imidacloprid is a neonicotinoid systemic insecticide used worldwide. In this study, the inclusion complexes of Imidacloprid (IMI) with ß-cyclodextrin (ß-CD) were prepared in the solid state by co-precipitation and the physical mixing method, with a stoichiometry of 11 and 12 molar ratios. The obtained products, Imidaclopridß-cyclodextrin inclusion complex (IMIß-CD), were characterized in the solid state by Fourier transform-infrared (FT-IR) spectroscopy and X-ray powder diffractometry (XRD). In solution, the 11 stoichiometry for the inclusion complexes was established by the Job plot method, and the binding constant of IMIß-CD was determined by UV-vis titration. The toxicity was determined in producers and primary consumers of the freshwater trophic chain, the green alga Raphidocelis subcapitata and the rotifer Brachionus calyciflorus, respectively. The results indicated that Imidacloprid forms inclusion complexes with CDs showing improved physicochemical properties compared to free Imidacloprid. The formation of the inclusion complex reduced the chronic toxicity in rotifers when IMI concentrations were close to those of environmental concern (tenths/hundredths of micromoles/L). Therefore, CD inclusion complexes could provide important advantages to be considered for the future industrial production of new formulations.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ciclodextrinas
/
Beta-Ciclodextrinas
Idioma:
En
Revista:
Molecules
Assunto da revista:
BIOLOGIA
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Itália