Surface Modification of Oxygenator Fibers with a Catalytically Active Metal-Organic Framework to Generate Nitric Oxide: An Ex Vivo Pilot Study.
ACS Appl Bio Mater
; 6(5): 1953-1959, 2023 05 15.
Article
em En
| MEDLINE
| ID: mdl-37068205
ABSTRACT
Coating all portions of an extracorporeal membrane oxygenation (ECMO) circuit with materials exhibiting inherent, permanent antithrombotic properties is an essential step to prevent thrombus-induced complications. However, developing antithrombotic coatings for oxygenator fibers within membrane oxygenators of ECMO systems has proven challenging. We have used polydopamine (PDA) to coat oxygenator fibers and immobilize a Cu-based metal-organic framework (MOF) on the surface to act as a nitric oxide (NO) catalyst. Importantly, the PDA/MOF coating will produce NO indefinitely from endogenous S-nitrosothiols and it has not previously been applied to ECMO oxygenator fibers.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Estruturas Metalorgânicas
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Óxido Nítrico
Idioma:
En
Revista:
ACS Appl Bio Mater
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Estados Unidos