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Design, synthesis and biological evaluation of pyrrolopyrimidine derivatives as novel and selective positive modulator of the small conductance Ca2+-activated K+ channels.
Guo, Ran; Cui, Miao; Li, Xiaojing; Wu, Mengqi; Xu, Fei; Zhang, Yining; Wang, Chun; Feng, Penglei; Wang, Jianchao; Huo, Sijia; Luo, Zijun; Xing, Ruijuan; Gu, Jianmin; Shi, Xiaowei; Liu, Yi; Wang, Lei.
Afiliação
  • Guo R; Department of Medicinal Chemistry, School of Pharmacy, Hebei Medical University, Shijiazhuang, 050017, PR China.
  • Cui M; Department of Medicinal Chemistry, School of Pharmacy, Hebei Medical University, Shijiazhuang, 050017, PR China.
  • Li X; Department of Medicinal Chemistry, School of Pharmacy, Hebei Medical University, Shijiazhuang, 050017, PR China.
  • Wu M; Department of Medicinal Chemistry, School of Pharmacy, Hebei Medical University, Shijiazhuang, 050017, PR China.
  • Xu F; Department of Medicinal Chemistry, School of Pharmacy, Hebei Medical University, Shijiazhuang, 050017, PR China.
  • Zhang Y; Department of Medicinal Chemistry, School of Pharmacy, Hebei Medical University, Shijiazhuang, 050017, PR China.
  • Wang C; Department of Medicinal Chemistry, School of Pharmacy, Hebei Medical University, Shijiazhuang, 050017, PR China.
  • Feng P; Department of Medicinal Chemistry, School of Pharmacy, Hebei Medical University, Shijiazhuang, 050017, PR China.
  • Wang J; Department of Medicinal Chemistry, School of Pharmacy, Hebei Medical University, Shijiazhuang, 050017, PR China.
  • Huo S; Department of Medicinal Chemistry, School of Pharmacy, Hebei Medical University, Shijiazhuang, 050017, PR China.
  • Luo Z; Department of Medicinal Chemistry, School of Pharmacy, Hebei Medical University, Shijiazhuang, 050017, PR China.
  • Xing R; Department of Medicinal Chemistry, School of Pharmacy, Hebei Medical University, Shijiazhuang, 050017, PR China.
  • Gu J; Department of Medicinal Chemistry, School of Pharmacy, Hebei Medical University, Shijiazhuang, 050017, PR China.
  • Shi X; Department of Medicinal Chemistry, School of Pharmacy, Hebei Medical University, Shijiazhuang, 050017, PR China. Electronic address: shixiaowei@hebmu.edu.cn.
  • Liu Y; Department of Toxicology, School of Public Health, Hebei Medical University, Shijiazhuang, 050017, PR China; Hebei Province Key Laboratory of Environment and Human Health, Shijiazhuang, 050017, PR China. Electronic address: liuyi78@hebmu.edu.cn.
  • Wang L; Department of Medicinal Chemistry, School of Pharmacy, Hebei Medical University, Shijiazhuang, 050017, PR China; Hebei Province Key Laboratory of Innovative Drug Research and Evaluation, Shijiazhuang, 050017, PR China. Electronic address: hmuwanglei@hebmu.edu.cn.
Eur J Med Chem ; 254: 115353, 2023 Jun 05.
Article em En | MEDLINE | ID: mdl-37068385
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirimidinas / Canais de Potássio Ativados por Cálcio de Condutância Baixa Tipo de estudo: Guideline Idioma: En Revista: Eur J Med Chem Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirimidinas / Canais de Potássio Ativados por Cálcio de Condutância Baixa Tipo de estudo: Guideline Idioma: En Revista: Eur J Med Chem Ano de publicação: 2023 Tipo de documento: Article