Epigenetic Modifiers as Game Changers for Healthy Aging.
Rejuvenation Res
; 26(3): 88-104, 2023 Jun.
Article
em En
| MEDLINE
| ID: mdl-37082972
ABSTRACT
Epigenetic alterations during aging are manifested with altered gene expression linking it to lifespan regulation, genetic instability, and diseases. Diet and epigenetic modifiers exert a profound effect on the lifespan of an organism by modulating the epigenetic marks. However, our understanding of the multifactorial nature of the epigenetic process during aging and the onset of disease conditions as well as its reversal by epidrugs, diet, or environmental factors is still mystifying. This review covers the key findings in epigenetics related to aging and age-related diseases. Furthermore, it holds a discussion about the epigenetic clocks and their implications in various age-related disease conditions, including cancer. Although, epigenetics is a reversible process, how fast the epigenetic alterations can revert to normal is an intriguing question. Therefore, this article touches on the possibility of utilizing nutrition and mesenchymal stem cell secretome to accelerate the epigenetic reversal and emphasizes the identification of new therapeutic epigenetic modifiers to counter epigenetic alteration during aging.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Envelhecimento Saudável
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
Rejuvenation Res
Assunto da revista:
FISIOLOGIA
/
GERIATRIA
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Índia