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Exploring Cefiderocol Resistance Mechanisms in Burkholderia pseudomallei.
Hall, Carina M; Somprasong, Nawarat; Hagen, Johannah P; Nottingham, Roxanne; Sahl, Jason W; Webb, Jessica R; Mayo, Mark; Currie, Bart J; Podin, Yuwana; Wagner, David M; Keim, Paul; Schweizer, Herbert P.
Afiliação
  • Hall CM; The Pathogen and Microbiome Institute, Northern Arizona University, Flagstaff, Arizona, USA.
  • Somprasong N; The Pathogen and Microbiome Institute, Northern Arizona University, Flagstaff, Arizona, USA.
  • Hagen JP; The Pathogen and Microbiome Institute, Northern Arizona University, Flagstaff, Arizona, USA.
  • Nottingham R; The Pathogen and Microbiome Institute, Northern Arizona University, Flagstaff, Arizona, USA.
  • Sahl JW; The Pathogen and Microbiome Institute, Northern Arizona University, Flagstaff, Arizona, USA.
  • Webb JR; Department of Biological Sciences, Northern Arizona University, Flagstaff, Arizona, USA.
  • Mayo M; Global and Tropical Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia.
  • Currie BJ; Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Australia.
  • Podin Y; Global and Tropical Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia.
  • Wagner DM; Global and Tropical Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia.
  • Keim P; Institute of Health and Community Medicine, Universiti Malaysia Sarawak, Sarawak, Malaysia.
  • Schweizer HP; The Pathogen and Microbiome Institute, Northern Arizona University, Flagstaff, Arizona, USA.
Antimicrob Agents Chemother ; 67(6): e0017123, 2023 06 15.
Article em En | MEDLINE | ID: mdl-37133377
ABSTRACT
Cefiderocol is a siderophore cephalosporin designed mainly for treatment of infections caused by ß-lactam and multidrug-resistant Gram-negative bacteria. Burkholderia pseudomallei clinical isolates are usually highly cefiderocol susceptible, with in vitro resistance found in a few isolates. Resistance in clinical B. pseudomallei isolates from Australia is caused by a hitherto uncharacterized mechanism. We show that, like in other Gram-negatives, the PiuA outer membrane receptor plays a major role in cefiderocol nonsusceptibility in isolates from Malaysia.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Burkholderia pseudomallei / Antibacterianos Idioma: En Revista: Antimicrob Agents Chemother Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Burkholderia pseudomallei / Antibacterianos Idioma: En Revista: Antimicrob Agents Chemother Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos