A facile, one-pot reductive alkylation of aromatic and heteroaromatic amines in aqueous micellar media: a chemoenzymatic approach.
Org Biomol Chem
; 21(20): 4264-4268, 2023 May 24.
Article
em En
| MEDLINE
| ID: mdl-37139595
ABSTRACT
A facile, green, selective and practical method for the catalytic N-alkylation of amines using molecular hydrogen as the reductant was developed. This procedure involves a lipase-mediated one-pot chemoenzymatic cascade wherein an amine undergoes a reductive amination with an aldehyde generated in situ. The imine formed thereby is reduced to give the corresponding amine. This process represents a convenient, environmentally benign and scalable one-pot process for the synthesis of N-alkyl amines. We report for the first time chemoenzymatic reductive alkylation in aqueous micellar media with an E-factor of 0.68.
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Org Biomol Chem
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Índia