Apigenin Alleviated High-Fat-Diet-Induced Hepatic Pyroptosis by Mitophagy-ROS-CTSB-NLRP3 Pathway in Mice and AML12 Cells.

Meng, Zhuoqun; Gao, Min; Wang, Chunyun; Guan, Shuang; Zhang, DuoDuo; Lu, Jing

Meng, Zhuoqun; Gao, Min; Wang, Chunyun; Guan, Shuang; Zhang, DuoDuo; Lu, Jing.

Afiliação

Meng Z; Department of Food Quality and Safety, College of Food Science and Engineering, Jilin University, Changchun, Jilin 130062, People's Republic of China.
Gao M; Department of Food Quality and Safety, College of Food Science and Engineering, Jilin University, Changchun, Jilin 130062, People's Republic of China.
Wang C; Department of Pharmacology, College of Basic Medical Sciences, Jilin University, Changchun, Jilin 130062, People's Republic of China.
Guan S; Department of Food Quality and Safety, College of Food Science and Engineering, Jilin University, Changchun, Jilin 130062, People's Republic of China.
Zhang D; Department of Thoracic Surgery, The First Hospital of Jilin University, Changchun, Jilin 130021, People's Republic of China.
Lu J; Department of Food Quality and Safety, College of Food Science and Engineering, Jilin University, Changchun, Jilin 130062, People's Republic of China.

J Agric Food Chem ; 71(18): 7032-7045, 2023 May 10.

Article em En | MEDLINE | ID: mdl-37141464

Assuntos

Inflamassomos; Proteína 3 que Contém Domínio de Pirina da Família NLR; Camundongos; Animais; Proteína 3 que Contém Domínio de Pirina da Família NLR/genética; Proteína 3 que Contém Domínio de Pirina da Família NLR/metabolismo; Inflamassomos/genética; Inflamassomos/metabolismo; Catepsina B/metabolismo; Espécies Reativas de Oxigênio/metabolismo; Apigenina/farmacologia; Apigenina/metabolismo; Interleucina-18/genética; Interleucina-18/metabolismo; Piroptose; Caspase 1/metabolismo; Dieta Hiperlipídica/efeitos adversos; Mitofagia; Camundongos Endogâmicos C57BL; Fígado/metabolismo

Palavras-chave

HFD; apigenin; liver injury; mitophagy-ROS-CTSB-NLRP3 pathway; pyroptosis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inflamassomos / Proteína 3 que Contém Domínio de Pirina da Família NLR Limite: Animals Idioma: En Revista: J Agric Food Chem Ano de publicação: 2023 Tipo de documento: Article País de publicação: Estados Unidos

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