High quality diet attenuated the positive association between polychlorinated biphenyls and premature mortality among middle-aged and older adults.
Environ Res
; 231(Pt 2): 116031, 2023 08 15.
Article
em En
| MEDLINE
| ID: mdl-37156355
ABSTRACT
OBJECTIVE:
Polychlorinated biphenyls (PCBs) have been reported to be a risk factor for premature death, while a high diet quality is thought to lower mortality risk. We aimed to examine whether PCBs were associated with higher all-cause and cause-specific mortality risk and whether such associations could be modified by the diet quality among US middle-aged and older adults.METHODS:
Included were 1259 participants aged 40 years or older from the 1999-2004 National Health and Nutrition Examination surveys. Exposure to PCBs was assessed in non-fasting serum samples, and mortality status was ascertained through December 31, 2019 using the public-use, linked mortality files. Diet quality was assessed using the Healthy Eating Index-2015 based on 24-h dietary recalls. Cox proportional hazard regression was applied to assess the associations of different PCB congener groups with mortality and the modifying effect by the diet quality.RESULTS:
During a median follow-up of 17.75 years, 419 deaths occurred, including 131 from cardiovascular disease (CVD) and 102 from cancer. Serum concentrations of dioxin-like PCBs and non-dioxin-like PCBs were significantly associated with all-cause mortality, with hazard ratios (HRs) of 1.84 (95% confidence interval [CI], 1.10, 2.99) and 1.82 (1.09, 3.03) for extreme-tertile comparisons. A significant interaction was noted between dioxin-like PCBs and diet quality (P for interaction 0.012), with a substantially more pronounced association among participants with a low diet quality (HR, 3.47; 95% CI 1.29, 9.32), compared to those with a high diet quality (HR, 0.98; 95% CI 0.40, 2.43). A similar weaker association was observed for total PCBs in participants with a high diet quality (P for interaction 0.032). However, effect modifications by diet quality were not noted for the associations between different PCB groups and CVD mortality.CONCLUSIONS:
While our findings need to be validated in other populations and mechanistic studies, they may suggest that a high quality diet could potentially attenuate the harmful effects of chronic PCB exposure.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças Cardiovasculares
/
Bifenilos Policlorados
/
Dioxinas
Tipo de estudo:
Risk_factors_studies
Limite:
Aged
/
Humans
/
Middle aged
Idioma:
En
Revista:
Environ Res
Ano de publicação:
2023
Tipo de documento:
Article
País de publicação:
HOLANDA
/
HOLLAND
/
NETHERLANDS
/
NL
/
PAISES BAJOS
/
THE NETHERLANDS