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Genetic architecture of the inflammatory bowel diseases across East Asian and European ancestries.
Liu, Zhanju; Liu, Ruize; Gao, Han; Jung, Seulgi; Gao, Xiang; Sun, Ruicong; Liu, Xiaoming; Kim, Yongjae; Lee, Ho-Su; Kawai, Yosuke; Nagasaki, Masao; Umeno, Junji; Tokunaga, Katsushi; Kinouchi, Yoshitaka; Masamune, Atsushi; Shi, Wenzhao; Shen, Chengguo; Guo, Zhenglin; Yuan, Kai; Zhu, Shu; Li, Dalin; Liu, Jianjun; Ge, Tian; Cho, Judy; Daly, Mark J; McGovern, Dermot P B; Ye, Byong Duk; Song, Kyuyoung; Kakuta, Yoichi; Li, Mingsong; Huang, Hailiang.
Afiliação
  • Liu Z; Center for IBD Research, Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China. zhanjuliu@tongji.edu.cn.
  • Liu R; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
  • Gao H; Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Jung S; Center for IBD Research, Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
  • Gao X; Department of Biochemistry and Molecular Biology, University of Ulsan College of Medicine, Seoul, Korea.
  • Sun R; Center for IBD Research, Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
  • Liu X; Center for IBD Research, Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
  • Kim Y; Inflammatory Bowel Diseases Research Center, Department of Gastroenterology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
  • Lee HS; Department of Biochemistry and Molecular Biology, University of Ulsan College of Medicine, Seoul, Korea.
  • Kawai Y; Department of Biochemistry and Molecular Biology, University of Ulsan College of Medicine, Seoul, Korea.
  • Nagasaki M; Genome Medical Science Project, National Center for Global Health and Medicine, Tokyo, Japan.
  • Umeno J; Human Biosciences Unit for the Top Global Course Center for the Promotion of Interdisciplinary Education and Research, Kyoto University, Kyoto, Japan.
  • Tokunaga K; Center for Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
  • Kinouchi Y; Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
  • Masamune A; Genome Medical Science Project, National Center for Global Health and Medicine, Tokyo, Japan.
  • Shi W; Student Healthcare Center, Institute for Excellence in Higher Education, Tohoku University, Sendai, Japan.
  • Shen C; Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan.
  • Guo Z; Digital Health China Technologies Corp Ltd., Beijing, China.
  • Yuan K; Digital Health China Technologies Corp Ltd., Beijing, China.
  • Ge T; Institute of Immunology, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
  • Cho J; Widjaja Inflammatory Bowel Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
  • Daly MJ; Genome Institute of Singapore, Singapore, Singapore.
  • McGovern DPB; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
  • Ye BD; Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  • Song K; Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
  • Kakuta Y; Center for Precision Psychiatry, Massachusetts General Hospital, Boston, MA, USA.
  • Li M; Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Huang H; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Nat Genet ; 55(5): 796-806, 2023 05.
Article em En | MEDLINE | ID: mdl-37156999
ABSTRACT
Inflammatory bowel diseases (IBDs) are chronic disorders of the gastrointestinal tract with the following two subtypes Crohn's disease (CD) and ulcerative colitis (UC). To date, most IBD genetic associations were derived from individuals of European (EUR) ancestries. Here we report the largest IBD study of individuals of East Asian (EAS) ancestries, including 14,393 cases and 15,456 controls. We found 80 IBD loci in EAS alone and 320 when meta-analyzed with ~370,000 EUR individuals (~30,000 cases), among which 81 are new. EAS-enriched coding variants implicate many new IBD genes, including ADAP1 and GIT2. Although IBD genetic effects are generally consistent across ancestries, genetics underlying CD appears more ancestry dependent than UC, driven by allele frequency (NOD2) and effect (TNFSF15). We extended the IBD polygenic risk score (PRS) by incorporating both ancestries, greatly improving its accuracy and highlighting the importance of diversity for the equitable deployment of PRS.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Inflamatórias Intestinais / Colite Ulcerativa / Doença de Crohn Limite: Humans Idioma: En Revista: Nat Genet Assunto da revista: GENETICA MEDICA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Inflamatórias Intestinais / Colite Ulcerativa / Doença de Crohn Limite: Humans Idioma: En Revista: Nat Genet Assunto da revista: GENETICA MEDICA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China