Prevalent stroke, age of its onset, and post-stroke lifestyle in relation to dementia: A prospective cohort study.
Alzheimers Dement
; 19(9): 3998-4007, 2023 09.
Article
em En
| MEDLINE
| ID: mdl-37157186
ABSTRACT
INTRODUCTION:
The association of age at stroke onset with dementia and the role of post-stroke lifestyle on dementia risk remains unclear.METHODS:
We leveraged data of 496,251 dementia-free participants from UK Biobank and explored the relationship between age at stroke onset and incident dementia. Among 8328 participants with stroke history, we further investigated the association of a healthy lifestyle with risk of dementia.RESULTS:
Participants with stroke history had a higher risk of dementia (hazard ratio [HR], 2.02). The association was stronger among participants with stroke onset at a younger age (≤50 HR, 2.63) compared with those at the age > 50 years (50-60 HR, 2.17; ≥60 HR, 1.58). Among participants with stroke history, a favorable lifestyle was associated with a lower risk of incident dementia.DISCUSSION:
Stroke onset in earlier life stage predicted a higher risk for dementia, but a favorable post-stroke lifestyle may protect against dementia.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Acidente Vascular Cerebral
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
/
Middle aged
Idioma:
En
Revista:
Alzheimers Dement
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
China