Development of VHL-recruiting STING PROTACs that suppress innate immunity.

Zhu, Zhichuan; Johnson, Rebecca L; Zhang, Zhigang; Herring, Laura E; Jiang, Guochun; Damania, Blossom; James, Lindsey I; Liu, Pengda

Zhu, Zhichuan; Johnson, Rebecca L; Zhang, Zhigang; Herring, Laura E; Jiang, Guochun; Damania, Blossom; James, Lindsey I; Liu, Pengda.

Afiliação

Zhu Z; Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Johnson RL; Department of Biochemistry and Biophysics, The University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Zhang Z; Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Herring LE; Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Jiang G; Department of Microbiology and Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Damania B; UNC Proteomics Core Facility, Department of Pharmacology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
James LI; Department of Biochemistry and Biophysics, The University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Liu P; UNC HIV Cure Center, Institute of Global Health and Infectious Diseases, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Cell Mol Life Sci ; 80(6): 149, 2023 05 14.

Article em En | MEDLINE | ID: mdl-37183204

Assuntos

Carcinoma de Células Renais; Neoplasias Renais; Humanos; Quimera de Direcionamento de Proteólise; Carcinoma de Células Renais/tratamento farmacológico; Ubiquitina-Proteína Ligases/metabolismo; Proteólise; Neoplasias Renais/tratamento farmacológico; Imunidade Inata; Proteína Supressora de Tumor Von Hippel-Lindau/genética; Proteína Supressora de Tumor Von Hippel-Lindau/metabolismo

Palavras-chave

Innate immunity; PROTAC; RCC; STING; VHL

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma de Células Renais / Neoplasias Renais Limite: Humans Idioma: En Revista: Cell Mol Life Sci Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Suíça

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google