Coupled oscillator cooperativity as a control mechanism in chronobiology.
Cell Syst
; 14(5): 382-391.e5, 2023 05 17.
Article
em En
| MEDLINE
| ID: mdl-37201507
ABSTRACT
Control of dynamical processes is vital for maintaining correct cell regulation and cell-fate decisions. Numerous regulatory networks show oscillatory behavior; however, our knowledge of how one oscillator behaves when stimulated by two or more external oscillatory signals is still missing. We explore this problem by constructing a synthetic oscillatory system in yeast and stimulate it with two external oscillatory signals. Letting model verification and prediction operate in a tight interplay with experimental observations, we find that stimulation with two external signals expands the plateau of entrainment and reduces the fluctuations of oscillations. Furthermore, by adjusting the phase differences of external signals, one can control the amplitude of oscillations, which is understood through the signal delay of the unperturbed oscillatory network. With this we reveal a direct amplitude dependency of downstream gene transcription. Taken together, these results suggest a new path to control oscillatory systems by coupled oscillator cooperativity.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fenômenos Cronobiológicos
/
Ciclo Celular
/
Diferenciação Celular
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
Cell Syst
Ano de publicação:
2023
Tipo de documento:
Article