YAP1 synergize with YY1 transcriptional co-repress DUSP1 to induce osimertinib resistant by activating the EGFR/MAPK pathway and abrogating autophagy in non-small cell lung cancer.

Ning, Yue; Zheng, Hongmei; Yang, Yang; Zang, Hongjing; Wang, Weiyuan; Zhan, Yuting; Wang, Haihua; Luo, Jiadi; Wen, Qiuyuan; Peng, Jinwu; Xiang, Juanjuan; Fan, Songqing

Ning, Yue; Zheng, Hongmei; Yang, Yang; Zang, Hongjing; Wang, Weiyuan; Zhan, Yuting; Wang, Haihua; Luo, Jiadi; Wen, Qiuyuan; Peng, Jinwu; Xiang, Juanjuan; Fan, Songqing.

Afiliação

Ning Y; Department of Pathology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Zheng H; Department of Pathology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Yang Y; Department of Pathology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Zang H; Department of Pathology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Wang W; Department of Pathology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Zhan Y; Department of Pathology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Wang H; Department of Pathology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Luo J; Department of Pathology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Wen Q; Department of Pathology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Peng J; Department of Pathology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Xiang J; Cancer Research Institute, Central South University, Changsha, Hunan, China.
Fan S; Department of Pathology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.

Int J Biol Sci ; 19(8): 2458-2474, 2023.

Article em En | MEDLINE | ID: mdl-37215986

Assuntos

Carcinoma Pulmonar de Células não Pequenas; Neoplasias Pulmonares; Humanos; Carcinoma Pulmonar de Células não Pequenas/tratamento farmacológico; Carcinoma Pulmonar de Células não Pequenas/genética; Carcinoma Pulmonar de Células não Pequenas/patologia; Neoplasias Pulmonares/tratamento farmacológico; Neoplasias Pulmonares/genética; Neoplasias Pulmonares/patologia; Receptores ErbB/genética; Resistencia a Medicamentos Antineoplásicos/genética; Autofagia/genética; Quinases de Proteína Quinase Ativadas por Mitógeno; Mutação; Linhagem Celular Tumoral; Fosfatase 1 de Especificidade Dupla/genética; Fator de Transcrição YY1

Palavras-chave

Autophagy; EGFR-TKI; Hippo pathway; Osimertinib; YAP1

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma Pulmonar de Células não Pequenas / Neoplasias Pulmonares Limite: Humans Idioma: En Revista: Int J Biol Sci Assunto da revista: BIOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China País de publicação: Austrália

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