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Supraphysiological FOXP3 expression in human CAR-Tregs results in improved stability, efficacy, and safety of CAR-Treg products for clinical application.
Henschel, Pierre; Landwehr-Kenzel, Sybille; Engels, Niklas; Schienke, Andrea; Kremer, Jakob; Riet, Tobias; Redel, Nella; Iordanidis, Konstantinos; Saetzler, Valerie; John, Katharina; Heider, Miriam; Hardtke-Wolenski, Matthias; Wedemeyer, Heiner; Jaeckel, Elmar; Noyan, Fatih.
Afiliação
  • Henschel P; Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Hannover, Germany.
  • Landwehr-Kenzel S; Institute of Transfusion Medicine and Transplant Engineering, Hannover Medical School, Hannover, Germany.
  • Engels N; Institute for Cellular and Molecular Immunology, University Medical Center Göttingen, Goettingen, Germany.
  • Schienke A; Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Hannover, Germany.
  • Kremer J; Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Hannover, Germany.
  • Riet T; Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Hannover, Germany; Department I of Internal Medicine, Tumor Genetics, University Hospital of Cologne and Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.
  • Redel N; Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Hannover, Germany.
  • Iordanidis K; Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Hannover, Germany.
  • Saetzler V; Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Hannover, Germany.
  • John K; Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Hannover, Germany.
  • Heider M; Institute for Laboratory Animal Science and Central Animal Facility, Hannover Medical School, Hannover, Germany.
  • Hardtke-Wolenski M; Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Hannover, Germany; Institute of Medical Microbiology, Essen University Hospital, University Duisburg-Essen, Essen, Germany.
  • Wedemeyer H; Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Hannover, Germany.
  • Jaeckel E; Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Hannover, Germany; Department of Liver Transplantation, Multi Organ Transplant Program, University Health Network, Toronto, University of Toronto, Canada.
  • Noyan F; Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Hannover, Germany. Electronic address: noyan.fatih@mh-hannover.de.
J Autoimmun ; 138: 103057, 2023 07.
Article em En | MEDLINE | ID: mdl-37224732
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Autoimunes / Receptores de Antígenos Quiméricos Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: J Autoimmun Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Alemanha
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Autoimunes / Receptores de Antígenos Quiméricos Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: J Autoimmun Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Alemanha