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Chiral 2-azabicycloalkanes bearing 1,2,3-triazole, thiourea, and ebselen moieties - Synthesis and biological activity.
Steppeler, Franz; Iwan, Dominika; Gaida, Radoslaw; Denel-Bobrowska, Marta; Olejniczak, Agnieszka B; Wojaczynska, Elzbieta.
Afiliação
  • Steppeler F; Faculty of Chemistry, Wroclaw University of Science and Technology, Wybrzeze Wyspianskiego 27, 50 370 Wroclaw, Poland.
  • Iwan D; Faculty of Chemistry, Wroclaw University of Science and Technology, Wybrzeze Wyspianskiego 27, 50 370 Wroclaw, Poland.
  • Gaida R; Faculty of Chemistry, Wroclaw University of Science and Technology, Wybrzeze Wyspianskiego 27, 50 370 Wroclaw, Poland.
  • Denel-Bobrowska M; Screening Laboratory, Institute of Medical Biology PAS, 106 Lodowa St., 93-232 Lódz, Poland.
  • Olejniczak AB; Screening Laboratory, Institute of Medical Biology PAS, 106 Lodowa St., 93-232 Lódz, Poland.
  • Wojaczynska E; Faculty of Chemistry, Wroclaw University of Science and Technology, Wybrzeze Wyspianskiego 27, 50 370 Wroclaw, Poland. Electronic address: elzbieta.wojaczynska@pwr.edu.pl.
Biomed Pharmacother ; 164: 114908, 2023 Aug.
Article em En | MEDLINE | ID: mdl-37224757
ABSTRACT
2-Azabicycloalkanes 2-azabicyclo[2.2.1]heptane and 2-azabicyclo[3.2.1]octane were used as a chiral platform for the construction of a set of 1,2,3-triazole, thiourea, and ebselen derivatives. Cytotoxicity and antiviral activity studies revealed the most promising potency for selected thioureas.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tioureia / Compostos Organosselênicos Idioma: En Revista: Biomed Pharmacother Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Polônia
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tioureia / Compostos Organosselênicos Idioma: En Revista: Biomed Pharmacother Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Polônia