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The Pyridotriazole Works as a Traceless Directing Group: A C-H Activation/Annulation Cascade Reaction with Iodonium Ylides.
Lv, Guanghui; Zhang, Qingyao; Zhang, Cuimei; Chen, Yuting; Lin, Zheng; Lai, Ruizhi; Yang, Zhongzhen; Wu, Yong.
Afiliação
  • Lv G; Key Laboratory of Drug-Targeting and Drug Delivery System of Education Ministry, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, No. 17, Third Section, South Renmin Road, Chengdu, Sichuan 610041, P. R. China.
  • Zhang Q; Department of Pharmacy, Taihe Hospital, Hubei University of Medicine, No. 32 South Renmin Road, Shiyan, Hubei 442000, China.
  • Zhang C; Key Laboratory of Drug-Targeting and Drug Delivery System of Education Ministry, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, No. 17, Third Section, South Renmin Road, Chengdu, Sichuan 610041, P. R. China.
  • Chen Y; Key Laboratory of Drug-Targeting and Drug Delivery System of Education Ministry, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, No. 17, Third Section, South Renmin Road, Chengdu, Sichuan 610041, P. R. China.
  • Lin Z; Key Laboratory of Drug-Targeting and Drug Delivery System of Education Ministry, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, No. 17, Third Section, South Renmin Road, Chengdu, Sichuan 610041, P. R. China.
  • Lai R; Key Laboratory of Drug-Targeting and Drug Delivery System of Education Ministry, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, No. 17, Third Section, South Renmin Road, Chengdu, Sichuan 610041, P. R. China.
  • Yang Z; Key Laboratory of Drug-Targeting and Drug Delivery System of Education Ministry, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, No. 17, Third Section, South Renmin Road, Chengdu, Sichuan 610041, P. R. China.
  • Wu Y; Key Laboratory of Drug-Targeting and Drug Delivery System of Education Ministry, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, No. 17, Third Section, South Renmin Road, Chengdu, Sichuan 610041, P. R. China.
Org Lett ; 25(22): 4022-4027, 2023 Jun 09.
Article em En | MEDLINE | ID: mdl-37232496
A novel Rh-catalyzed cascade reaction of pyridotriazoles with iodonium ylides is reported. This one-pot procedure involves a triazole-directed ortho-position C-H carbene insertion, followed by intramolecular denitrogenation annulation. It was noteworthy that this reaction provided straightforward access to 1H-isochromene frameworks with excellent yields (up to 94% yield).
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Triazóis Idioma: En Revista: Org Lett Assunto da revista: BIOQUIMICA Ano de publicação: 2023 Tipo de documento: Article País de publicação: Estados Unidos
Texto completo
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Triazóis Idioma: En Revista: Org Lett Assunto da revista: BIOQUIMICA Ano de publicação: 2023 Tipo de documento: Article País de publicação: Estados Unidos