Synthesis and evaluation of piperazinotriazoles. Discovery of a potent and orally bioavailable neurokinin-3 receptor inhibitor.

Ye, Liang; Yang, Yifei; Li, Chunmei; Zhang, Jianzhao; Wang, Wenyan; Ma, Mingxu; Xu, Hengwei; Zhang, Wenjing; Zou, Fangxia; Hu, Zhengping; Wang, Hongbo; Tian, Jingwei

Ye, Liang; Yang, Yifei; Li, Chunmei; Zhang, Jianzhao; Wang, Wenyan; Ma, Mingxu; Xu, Hengwei; Zhang, Wenjing; Zou, Fangxia; Hu, Zhengping; Wang, Hongbo; Tian, Jingwei.

Afiliação

Ye L; School of Public Health and Management, Binzhou Medical University, Yantai, PR China. Electronic address: project0088@hotmail.com.
Yang Y; School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, 264005, PR China.
Li C; School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, 264005, PR China.
Zhang J; College of Life Sciences, Yantai University, Yantai, Shangdong, 264005, PR China.
Wang W; School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, 264005, PR China.
Ma M; School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, 264005, PR China.
Xu H; R & D Center, Luye Pharma Group Ltd., Yantai, 264003, PR China.
Zhang W; R & D Center, Luye Pharma Group Ltd., Yantai, 264003, PR China.
Zou F; School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, 264005, PR China.
Hu Z; Medicine & Pharmacy Research Center, Binzhou Medical University, Yantai, PR China.
Wang H; School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, 264005, PR China. Electronic address
Tian J; School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, 264005, PR China. Electronic address

Eur J Med Chem ; 257: 115486, 2023 Sep 05.

Article em En | MEDLINE | ID: mdl-37247507

Assuntos

Neurocinina B; Receptores da Neurocinina-3; Feminino; Humanos; Simulação de Acoplamento Molecular; Transdução de Sinais; Ovariectomia

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neurocinina B / Receptores da Neurocinina-3 Tipo de estudo: Prognostic_studies Limite: Female / Humans Idioma: En Revista: Eur J Med Chem Ano de publicação: 2023 Tipo de documento: Article País de publicação: França

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