Quantitative histochemistry of brain acetylcholinesterase and learning rate in the aged rat.
Neurobiol Aging
; 7(3): 215-7, 1986.
Article
em En
| MEDLINE
| ID: mdl-3724956
ABSTRACT
Using a newly developed method for quantitative acetylcholinesterase (AChE) histochemistry we find a substantial decrease in AChE content in aged rats compared to young controls in the cholinergic cell body regions (the ventral pallidum and the medial septal nuclei) and, to a smaller extent in the projection areas (the cortex and hippocampus). In the same group of aged rats we find a severe deficit in the acquisition of a water maze task. Quantitative histochemistry is a potent method for detecting localized changes in AChE content in otherwise intact, learning-impaired aged rats.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Acetilcolinesterase
/
Encéfalo
/
Envelhecimento
/
Aprendizagem
Limite:
Animals
Idioma:
En
Revista:
Neurobiol Aging
Ano de publicação:
1986
Tipo de documento:
Article