Your browser doesn't support javascript.
loading
The MIF promoter SNP rs755622 is associated with immune activation in glioblastoma.
Alban, Tyler J; Grabowski, Matthew M; Otvos, Balint; Bayik, Defne; Wang, Wesley; Zalavadia, Ajay; Makarov, Vlad; Troike, Katie; McGraw, Mary; Rabljenovic, Anja; Lauko, Adam; Neumann, Chase; Roversi, Gustavo; Waite, Kristin A; Cioffi, Gino; Patil, Nirav; Tran, Thuy T; McCortney, Kathleen; Steffens, Alicia; Diaz, C Marcela; Brown, J Mark; Egan, Kathleen M; Horbinski, Craig M; Barnholtz-Sloan, Jill S; Rajappa, Prajwal; Vogelbaum, Michael A; Bucala, Richard; Chan, Timothy A; Ahluwalia, Manmeet S; Lathia, Justin D.
Afiliação
  • Alban TJ; Department of Cardiovascular & Metabolic Sciences and Imaging Core, Lerner Research Institute.
  • Grabowski MM; Center for Immunotherapy and Precision Oncology, and.
  • Otvos B; Rose Ella Burkhardt Brain Tumor and Neuro-Oncology Center, Cleveland Clinic, Cleveland, Ohio, USA.
  • Bayik D; Rose Ella Burkhardt Brain Tumor and Neuro-Oncology Center, Cleveland Clinic, Cleveland, Ohio, USA.
  • Wang W; Department of Cardiovascular & Metabolic Sciences and Imaging Core, Lerner Research Institute.
  • Zalavadia A; Nationwide Children's Hospital, Institute for Genomic Medicine, Departments of Pediatrics and Neurological Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
  • Makarov V; Department of Cardiovascular & Metabolic Sciences and Imaging Core, Lerner Research Institute.
  • Troike K; Center for Immunotherapy and Precision Oncology, and.
  • McGraw M; Department of Cardiovascular & Metabolic Sciences and Imaging Core, Lerner Research Institute.
  • Rabljenovic A; Rose Ella Burkhardt Brain Tumor and Neuro-Oncology Center, Cleveland Clinic, Cleveland, Ohio, USA.
  • Lauko A; Department of Cardiovascular & Metabolic Sciences and Imaging Core, Lerner Research Institute.
  • Neumann C; Department of Cardiovascular & Metabolic Sciences and Imaging Core, Lerner Research Institute.
  • Roversi G; Department of Cardiovascular & Metabolic Sciences and Imaging Core, Lerner Research Institute.
  • Waite KA; Department of Cardiovascular & Metabolic Sciences and Imaging Core, Lerner Research Institute.
  • Cioffi G; Division of Cancer Epidemiology and Genetics, Trans-Divisional Research Program, Center for Biomedical Informatics and Information Technology, National Cancer Institute, Bethesda, Maryland, USA.
  • Patil N; Division of Cancer Epidemiology and Genetics, Trans-Divisional Research Program, Center for Biomedical Informatics and Information Technology, National Cancer Institute, Bethesda, Maryland, USA.
  • Tran TT; University Hospitals Research and Education Institute, Cleveland, Ohio, USA.
  • McCortney K; Yale School of Medicine and Yale Cancer Center, New Haven, Connecticut, USA.
  • Steffens A; Departments of Pathology and Neurosurgery, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA.
  • Diaz CM; Departments of Pathology and Neurosurgery, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA.
  • Brown JM; Center for Immunotherapy and Precision Oncology, and.
  • Egan KM; Department of Cardiovascular & Metabolic Sciences and Imaging Core, Lerner Research Institute.
  • Horbinski CM; Cleveland Clinic Lerner College of Medicine at Case Western Reserve University, Cleveland, Ohio, USA.
  • Barnholtz-Sloan JS; Case Comprehensive Cancer Center, Cleveland, Ohio, USA.
  • Rajappa P; Departments of Pathology and Neurosurgery, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA.
  • Vogelbaum MA; Departments of Pathology and Neurosurgery, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA.
  • Bucala R; Division of Cancer Epidemiology and Genetics, Trans-Divisional Research Program, Center for Biomedical Informatics and Information Technology, National Cancer Institute, Bethesda, Maryland, USA.
  • Chan TA; Nationwide Children's Hospital, Institute for Genomic Medicine, Departments of Pediatrics and Neurological Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
  • Ahluwalia MS; Departments of Cancer Epidemiology and Neuro-Oncology, H. Lee Moffitt Cancer Center, Tampa, Florida, USA.
  • Lathia JD; Yale School of Medicine and Yale Cancer Center, New Haven, Connecticut, USA.
JCI Insight ; 8(13)2023 07 10.
Article em En | MEDLINE | ID: mdl-37252795
ABSTRACT
Intratumoral heterogeneity is a defining hallmark of glioblastoma, driving drug resistance and ultimately recurrence. Many somatic drivers of microenvironmental change have been shown to affect this heterogeneity and, ultimately, the treatment response. However, little is known about how germline mutations affect the tumoral microenvironment. Here, we find that the single-nucleotide polymorphism (SNP) rs755622 in the promoter of the cytokine macrophage migration inhibitory factor (MIF) is associated with increased leukocyte infiltration in glioblastoma. Furthermore, we identified an association between rs755622 and lactotransferrin expression, which could also be used as a biomarker for immune-infiltrated tumors. These findings demonstrate that a germline SNP in the promoter region of MIF may affect the immune microenvironment and further reveal a link between lactotransferrin and immune activation.
Assuntos
Palavras-chave
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fatores Inibidores da Migração de Macrófagos / Glioblastoma Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: JCI Insight Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fatores Inibidores da Migração de Macrófagos / Glioblastoma Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: JCI Insight Ano de publicação: 2023 Tipo de documento: Article