Real-time in-line prediction of drug loading and release rate in the coating process of diclofenac sodium spheres based on near infrared spectroscopy.

Sun, Zhongyu; Zhang, Kefan; Lin, Boran; Huang, Ruiqi; Yang, Xiangchun; Li, Shuangshuang; Liang, Mengying; Nie, Lei; Yin, Wenping; Wang, Hui; Zhang, Hui; Li, Lian; Wu, Aoli; Zang, Hengchang

Sun, Zhongyu; Zhang, Kefan; Lin, Boran; Huang, Ruiqi; Yang, Xiangchun; Li, Shuangshuang; Liang, Mengying; Nie, Lei; Yin, Wenping; Wang, Hui; Zhang, Hui; Li, Lian; Wu, Aoli; Zang, Hengchang.

Afiliação

Sun Z; NMPA Key Laboratory for Technology Research and Evaluation of Drug Products, Institute of Biochemical and Biotechnological Drug, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, 250012, Shandong, China.
Zhang K; NMPA Key Laboratory for Technology Research and Evaluation of Drug Products, Institute of Biochemical and Biotechnological Drug, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, 250012, Shandong, China.
Lin B; NMPA Key Laboratory for Technology Research and Evaluation of Drug Products, Institute of Biochemical and Biotechnological Drug, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, 250012, Shandong, China.
Huang R; NMPA Key Laboratory for Technology Research and Evaluation of Drug Products, Institute of Biochemical and Biotechnological Drug, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, 250012, Shandong, China.
Yang X; NMPA Key Laboratory for Technology Research and Evaluation of Drug Products, Institute of Biochemical and Biotechnological Drug, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, 250012, Shandong, China.
Li S; NMPA Key Laboratory for Technology Research and Evaluation of Drug Products, Institute of Biochemical and Biotechnological Drug, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, 250012, Shandong, China.
Liang M; NMPA Key Laboratory for Technology Research and Evaluation of Drug Products, Institute of Biochemical and Biotechnological Drug, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, 250012, Shandong, China.
Nie L; NMPA Key Laboratory for Technology Research and Evaluation of Drug Products, Institute of Biochemical and Biotechnological Drug, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, 250012, Shandong, China.
Yin W; Shandong SMA Pharmatech Co., Ltd, Zibo, 255000, Shandong, China.
Wang H; Shandong SMA Pharmatech Co., Ltd, Zibo, 255000, Shandong, China.
Zhang H; NMPA Key Laboratory for Technology Research and Evaluation of Drug Products, Institute of Biochemical and Biotechnological Drug, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, 250012, Shandong, China.
Li L; NMPA Key Laboratory for Technology Research and Evaluation of Drug Products, Institute of Biochemical and Biotechnological Drug, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, 250012, Shandong, China; Key Laboratory of Chemical Biology (Ministry of Educat
Wu A; NMPA Key Laboratory for Technology Research and Evaluation of Drug Products, Institute of Biochemical and Biotechnological Drug, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, 250012, Shandong, China.
Zang H; NMPA Key Laboratory for Technology Research and Evaluation of Drug Products, Institute of Biochemical and Biotechnological Drug, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, 250012, Shandong, China; Key Laboratory of Chemical Biology (Ministry of Educat

Spectrochim Acta A Mol Biomol Spectrosc ; 301: 122952, 2023 Nov 15.

Article em En | MEDLINE | ID: mdl-37270976

Assuntos

Diclofenaco; Espectroscopia de Luz Próxima ao Infravermelho; Espectroscopia de Luz Próxima ao Infravermelho/métodos; Diclofenaco/química; Análise dos Mínimos Quadrados

Palavras-chave

Coating process; Drug loading; Near infrared spectroscopy; Real-time in-line prediction; Release rate

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diclofenaco / Espectroscopia de Luz Próxima ao Infravermelho Tipo de estudo: Prognostic_studies / Risk_factors_studies Idioma: En Revista: Spectrochim Acta A Mol Biomol Spectrosc Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China País de publicação: Reino Unido

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