CDN1163, an activator of sarco/endoplasmic reticulum Ca<sup>2+</sup> ATPase, up-regulates mitochondrial functions and protects against lipotoxicity in pancreatic ß-cells.

Nguyen, Ha Thu; Noriega Polo, Carlos; Wiederkehr, Andreas; Wollheim, Claes B; Park, Kyu-Sang

CDN1163, an activator of sarco/endoplasmic reticulum Ca²⁺ ATPase, up-regulates mitochondrial functions and protects against lipotoxicity in pancreatic ß-cells.

Nguyen, Ha Thu; Noriega Polo, Carlos; Wiederkehr, Andreas; Wollheim, Claes B; Park, Kyu-Sang.

Afiliação

Nguyen HT; Department of Physiology, Yonsei University Wonju College of Medicine, Wonju, South Korea.
Noriega Polo C; Mitohormesis Research Center, Yonsei University Wonju College of Medicine, Wonju, South Korea.
Wiederkehr A; Department of Physiology, Yonsei University Wonju College of Medicine, Wonju, South Korea.
Wollheim CB; Mitohormesis Research Center, Yonsei University Wonju College of Medicine, Wonju, South Korea.
Park KS; Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.

Br J Pharmacol ; 180(21): 2762-2776, 2023 11.

Article em En | MEDLINE | ID: mdl-37277321

Assuntos

Diabetes Mellitus Tipo 2; Camundongos; Animais; Diabetes Mellitus Tipo 2/metabolismo; Antioxidantes/farmacologia; Retículo Endoplasmático; Mitocôndrias/metabolismo; ATPases Transportadoras de Cálcio do Retículo Sarcoplasmático/metabolismo; Estresse do Retículo Endoplasmático; Palmitatos/metabolismo; Palmitatos/farmacologia; Cálcio/metabolismo

Palavras-chave

CDN1163; lipotoxicity; mitochondria; pancreatic ß-cell; sarco/endoplasmic reticulum Ca2+ ATPase

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diabetes Mellitus Tipo 2 Limite: Animals Idioma: En Revista: Br J Pharmacol Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Coréia do Sul País de publicação: Reino Unido

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