Ceftriaxone improves impairments in synaptic plasticity and cognitive behavior in APP/PS1 mouse model of Alzheimer's disease by inhibiting extrasynaptic NMDAR-STEP<sub>61</sub> signaling.

He, Ruo-Bing; Li, Li; Liu, Li-Zhe; Ma, Ya-Jun; Fan, Shu-Juan; Liu, Li-Rong; Li, Wen-Bin; Xian, Xiao-Hui

Ceftriaxone improves impairments in synaptic plasticity and cognitive behavior in APP/PS1 mouse model of Alzheimer's disease by inhibiting extrasynaptic NMDAR-STEP₆₁ signaling.

He, Ruo-Bing; Li, Li; Liu, Li-Zhe; Ma, Ya-Jun; Fan, Shu-Juan; Liu, Li-Rong; Li, Wen-Bin; Xian, Xiao-Hui.

Afiliação

He RB; Department of Pathophysiology, Neuroscience Research Center, Hebei Medical University, Shijiazhuang City, People's Republic of China.
Li L; Central Laboratory, The Second Hospital of Hebei Medical University, Shijiazhuang, People's Republic of China.
Liu LZ; Department of Pathophysiology, Neuroscience Research Center, Hebei Medical University, Shijiazhuang City, People's Republic of China.
Ma YJ; Department of Pathophysiology, Neuroscience Research Center, Hebei Medical University, Shijiazhuang City, People's Republic of China.
Fan SJ; Department of Pathophysiology, Neuroscience Research Center, Hebei Medical University, Shijiazhuang City, People's Republic of China.
Liu LR; Department of Pathophysiology, Neuroscience Research Center, Hebei Medical University, Shijiazhuang City, People's Republic of China.
Li WB; Department of Pathophysiology, Neuroscience Research Center, Hebei Medical University, Shijiazhuang City, People's Republic of China.
Xian XH; Department of Pathophysiology, Neuroscience Research Center, Hebei Medical University, Shijiazhuang City, People's Republic of China.

J Neurochem ; 166(2): 215-232, 2023 07.

Article em En | MEDLINE | ID: mdl-37284938

Assuntos

Doença de Alzheimer; Camundongos; Animais; Doença de Alzheimer/tratamento farmacológico; Doença de Alzheimer/metabolismo; Ceftriaxona/farmacologia; Ceftriaxona/uso terapêutico; Modelos Animais de Doenças; Plasticidade Neuronal/fisiologia; Cognição; Camundongos Transgênicos; Receptores de N-Metil-D-Aspartato/metabolismo

Palavras-chave

APP/PS1 AD mice; Alzheimer's disease; Extrasynaptic NMDAR; ceftriaxone; striatal enriched tyrosine phosphatase 61

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Alzheimer Limite: Animals Idioma: En Revista: J Neurochem Ano de publicação: 2023 Tipo de documento: Article País de publicação: Reino Unido

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google