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Potentiating the Cross-Reactive IFN-γ T Cell and Polyfunctional T Cell Responses by Heterologous GX-19N DNA Booster in Mice Primed with Either a COVID-19 mRNA Vaccine or Inactivated Vaccine.
Seo, Yong Bok; Ko, Ara; Shin, Duckhyang; Kim, Junyoung; Suh, You Suk; Na, Juyoung; Ryu, Ji In; Lee, Suyeon; Oh, Min Ji; Sung, Young Chul.
Afiliação
  • Seo YB; Research Institute, SL VaxiGen Inc., Korea Bio Park, Seongnam 13488, Republic of Korea.
  • Ko A; Research Institute, SL VaxiGen Inc., Korea Bio Park, Seongnam 13488, Republic of Korea.
  • Shin D; Research Institute, Genexine Inc., Korea Bio Park, Seongnam 13488, Republic of Korea.
  • Kim J; Research Institute, SL VaxiGen Inc., Korea Bio Park, Seongnam 13488, Republic of Korea.
  • Suh YS; Research Institute, Genexine Inc., Korea Bio Park, Seongnam 13488, Republic of Korea.
  • Na J; Research Institute, Genexine Inc., Korea Bio Park, Seongnam 13488, Republic of Korea.
  • Ryu JI; Research Institute, SL VaxiGen Inc., Korea Bio Park, Seongnam 13488, Republic of Korea.
  • Lee S; Research Institute, SL VaxiGen Inc., Korea Bio Park, Seongnam 13488, Republic of Korea.
  • Oh MJ; Research Institute, SL VaxiGen Inc., Korea Bio Park, Seongnam 13488, Republic of Korea.
  • Sung YC; Research Institute, Genexine Inc., Korea Bio Park, Seongnam 13488, Republic of Korea.
Int J Mol Sci ; 24(11)2023 Jun 05.
Article em En | MEDLINE | ID: mdl-37298704
Waning vaccine-induced immunity, coupled with the emergence of SARS-CoV-2 variants, has inspired the widespread implementation of COVID-19 booster vaccinations. Here, we evaluated the potential of the GX-19N DNA vaccine as a heterologous booster to enhance the protective immune response to SARS-CoV-2 in mice primed with either an inactivated virus particle (VP) or an mRNA vaccine. We found that in the VP-primed condition, GX-19N enhanced the response of both vaccine-specific antibodies and cross-reactive T Cells to the SARS-CoV-2 variant of concern (VOC), compared to the homologous VP vaccine prime-boost. Under the mRNA-primed condition, GX-19N induced higher vaccine-induced T Cell responses but lower antibody responses than the homologous mRNA vaccine prime-boost. Furthermore, the heterologous GX-19N boost induced higher S-specific polyfunctional CD4+ and CD8+ T cell responses than the homologous VP or mRNA prime-boost vaccinations. Our results provide new insights into booster vaccination strategies for the management of novel COVID-19 variants.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos T / Vacinas contra COVID-19 / COVID-19 Limite: Animals / Humans Idioma: En Revista: Int J Mol Sci Ano de publicação: 2023 Tipo de documento: Article País de publicação: Suíça

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos T / Vacinas contra COVID-19 / COVID-19 Limite: Animals / Humans Idioma: En Revista: Int J Mol Sci Ano de publicação: 2023 Tipo de documento: Article País de publicação: Suíça