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SRPX2 promotes cancer cell proliferation and migration of papillary thyroid cancer.
Guo, Haiwei; Liu, Ruiqi; Wu, Jiajun; Li, Shuang; Yao, Weiping; Xu, Jiajie; Zheng, Chuanming; Lu, Yanwei; Zhang, Haibo.
Afiliação
  • Guo H; Otolaryngology and Head and Neck Center, Cancer Center, Department of Head and Neck Surgery, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China.
  • Liu R; Key Laboratory of Endocrine Gland Diseases of Zhejiang Province, Hangzhou, Zhejiang, China.
  • Wu J; Clinical Research Center for Cancer of Zhejiang Province, Hangzhou, Zhejiang, China.
  • Li S; Cancer Center, Department of Radiation Oncology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China.
  • Yao W; Graduate Department, Bengbu Medical College, Bengbu, Anhui, China.
  • Xu J; Otolaryngology and Head and Neck Center, Cancer Center, Department of Head and Neck Surgery, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China.
  • Zheng C; Graduate Department, Bengbu Medical College, Bengbu, Anhui, China.
  • Lu Y; Key Laboratory of Endocrine Gland Diseases of Zhejiang Province, Hangzhou, Zhejiang, China.
  • Zhang H; Clinical Research Center for Cancer of Zhejiang Province, Hangzhou, Zhejiang, China.
Clin Exp Med ; 23(8): 4825-4834, 2023 Dec.
Article em En | MEDLINE | ID: mdl-37306872
ABSTRACT
Thyroid cancer is the endocrine tumor with the highest incidence at present. It originates from the thyroid follicular epithelium or follicular paraepithelial cells. There is an increasing incidence of thyroid cancer all over the world. We found that SRPX2 expression level was higher in papillary thyroid tumors than in normal thyroid tissues, and SRPX2 expression was closely related to tumor grade and clinical prognosis. Previous reports showed that SRPX2 could function by activating PI3K/AKT signaling pathway. In addition, in vitro experiments showed that SRPX2 promoted the proliferation and migration of papillary thyroid cancer (PTC). In conclusion, SRPX2 could promote the malignant development of PTC. This may be a potential treatment target for PTC.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Glândula Tireoide / Fosfatidilinositol 3-Quinases Limite: Humans Idioma: En Revista: Clin Exp Med Assunto da revista: MEDICINA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Glândula Tireoide / Fosfatidilinositol 3-Quinases Limite: Humans Idioma: En Revista: Clin Exp Med Assunto da revista: MEDICINA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China